| Long name: |
52, 88) Monoclonal Antibody, TERF2IP (1664CT564 |
| Also known as: |
52, 88) Monoclonal Antibody, TERF2IP (1664CT564 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TERF2IP |
| Specificity: |
This is a highly specific antibody against TERF2IP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1664CT564, 52, 88 |
| Source: |
This TERF2IP antibody is generated from a mouse immunized with a recombinant protein from human TERF2IP |
| Gene ID number: |
54386 |
| Swiss Prot: |
Q9NYB0 |
| Tested Applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2, In contrast to other components of the shelterin complex, Independently of its function in telomeres, Instead, Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome), When cytoplasmic, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), leading to activate expression of NF-kappa-B target genes, which can affect telomere length, Acts both as a regulator of telomere function and as a transcription regulator |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DRIP5, Dopamine receptor-interacting protein 5, PP8000, RAP1 homolog, Repressor/activator protein 1 homolog, TERF2-interacting telomeric protein 1, TERF2IP, TRF2-interacting telomeric protein 1, Telomeric repeat-binding factor 2-interacting protein 1, hRap1, RAP1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
52, 88) Monoclonal, TERF2IP (1664CT564 |
| Short name: |
52, 88) Monoclonal Antibody, TERF2IP (1664CT564 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
52, 88) monoclonal (Antibody to), TERF2IP (1664CT564 |
| Alternative technique: |
antibodies |
| Identity: |
19246 |
| Gene: |
TERF2IP |
More about : TERF2IP |
| Long gene name: |
TERF2 interacting protein |
| Synonyms gene name: |
interacting protein , telomeric repeat binding factor 2 |
| Synonyms: |
RAP1 |
| Locus: |
16q23, 1 |
| Discovery year: |
2002-09-18 |
| GenBank acession: |
AK000669 |
| Entrez gene record: |
54386 |
| Pubmed identfication: |
10850490 |
| RefSeq identity: |
NM_018975 |
| Classification: |
Shelterin complex |
| Havana BLAST/BLAT: |
OTTHUMG00000177136 |
| Locus Specific Databases: |
LRG_1084 |