| Long name: |
10, 26) Monoclonal Antibody, PCNA (1655CT506 |
| Also known as: |
10, 26) Monoclonal Antibody, PCNA (1655CT506 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PCNA |
| Specificity: |
This is a highly specific antibody against PCNA |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
10, 1655CT506, 26 |
| Source: |
This PCNA antibody is generated from a mouse immunized with a recombinant protein of human PCNA |
| Gene ID number: |
5111 |
| Swiss Prot: |
P12004 |
| Tested Applications: |
FCM, IHC-P, WB |
| Recommended dilutions: |
FC(1:25), WB(1:2000), IHC-P(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
APEX2 activities, Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, Has to be loaded onto DNA in order to be able to stimulate APEX2, Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902), but not apurinic-apyrimidinic (AP) endonuclease, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion, Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Cyclin, PCNA, Proliferating cell nuclear antigen, ATLD2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
10, 26) Monoclonal, PCNA (1655CT506 |
| Short name: |
10, 26) Monoclonal Antibody, PCNA (1655CT506 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
10, 26) monoclonal (Antibody to), PCNA (1655CT506 |
| Alternative technique: |
antibodies |
| Identity: |
8729 |
| Gene: |
PCNA |
More about : PCNA |
| Long gene name: |
proliferating cell nuclear antigen |
| Locus: |
20p12, 3 |
| Discovery year: |
1990-01-15 |
| GenBank acession: |
J04718 |
| Entrez gene record: |
5111 |
| Pubmed identfication: |
2565339 |
| Havana BLAST/BLAT: |
OTTHUMG00000031798 |