| Background of the target antigen: |
AMPH, APC, APC, BARD1, BIRC5/survivin, BRCA2, Bcl-xL/BCL2L1, CALD1, CASP8, CC2D1A, CDC20, CDC25A, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, CDC25C, CDC7, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs, CDK7, CEBPB, CHAMP1, CSNK2 proteins/CKII, DMD/dystrophin, During G2 and early mitosis, EEF1 proteins/EF-1, EEF1E1/p18, EGFR, EIF3F/p47, ESPL1, EZH2, Essential for early stages of embryonic development, FANCG, FOS, FOXO1, FZR1/CDH1, GFAP, GOLGA2/GM130, GRASP1, Golgi dynamics, HIST1H1 proteins/histone H1, HIVEP3/KRC, HMGA1, Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair, KHDRBS1/SAM68, KIF11/EG5, LATS1, LBR, LMNA, LMNB, LMNC, MAP1B, MAP4, MAPT/TAU, MARCKS, MCM2, MCM4, MKLP1, MYB, NCL, NEDD1, NEFH, NFIC, NONO/p54NRB, NPC/nuclear pore complex, NPM1, NPM1/numatrin, NUCKS1, ORC1, Once chromosomes are condensed and aligned at the metaphase plate, PAPOLA, PITPNM1/NIR2, PLEC/plectin, PRKAR2A, Phosphorylates PARVA/actopaxin, RAB4A, RAP1GAP, RB1, RCC1, RPS6KB1/S6K1, RUNX1/AML1, Required in higher cells for entry into S-phase and mitosis, SIRT2 and RUNX2, SKI, STIP1, TEX14, TK1, UBE2A/hHR6A, UL40/R2, VIM/vimentin, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins, beta-tubulins, chromosome decondensation, nuclear envelope breakdown and chromosome condensation, p53/TP53, promotes G2-M transition, reformation of the nuclear envelope and cytokinesis, Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset, osomes during mitosis (PubMed:26549230) |
| Alternative to gene target: |
CDC2 and CDC28A and P34CDC2, CDK1 and IDBG-628960 and ENSBTAG00000010109 and 281061, CDK1 and IDBG-75344 and ENSG00000170312 and 983, Cdk1 and IDBG-160472 and ENSMUSG00000019942 and 12534, nuclei, this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000083 and regulation of transcription involved in G1/S transition of mitotic cell cycle and biological process this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000165 and MAPK cascade and biological process this GO :0000186 and activation of MAPKK activity and biological process this GO :0000187 and activation of MAPK activity and biological process this GO :0000226 and microtubule cytoskeleton organization and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004693 and cyclin-dependent protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005813 and centrosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005876 and spindle microtubule and cellular component this GO :0006260 and DNA replication and biological process this GO :0006281 and DNA repair and biological process this GO :0006461 and protein complex assembly and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007067 and mitotic nuclear division and biological process this GO :0007077 and mitotic nuclear envelope disassembly and biological process this GO :0007095 and mitotic G2 DNA damage checkpoint and biological process this GO :0007098 and centrosome cycle and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007344 and pronuclear fusion and biological process this GO :0007411 and axon guidance and biological process this GO :0007569 and cell aging and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008353 and RNA polymerase II carboxy-terminal domain kinase activity and molecular function this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0014038 and regulation of Schwann cell differentiation and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0014075 and response to amine and biological process this GO :0014823 and response to activity and biological process this GO :0016020 and membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016477 and cell migration and biological process this GO :0016572 and histone phosphorylation and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004693 : cyclin-dependent protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008353 : RNA polymerase II carboxy-terminal domain kinase activity and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004693 : cyclin-dependent protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008353 : RNA polymerase II carboxy-terminal domain kinase activity, this GO :0016301 : kinase activity, this GO :0016772 : transferase activity, this GO :0030332 : cyclin binding, this GO :0030544 : Hsp70 protein binding, this GO :0035173 : histone kinase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0030332 : cyclin binding and also this GO :0030544 : Hsp70 protein binding and also this GO :0035173 : histone kinase activity, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0030261 and chromosome condensation and biological process this GO :0030332 and cyclin binding and molecular function this GO :0030496 and midbody and cellular component this GO :0030544 and Hsp70 protein binding and molecular function this GO :0030855 and epithelial cell differentiation and biological process this GO :0031100 and organ regeneration and biological process this GO :0031145 and anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0033160 and positive regulation of protein import into nucleus, translocation and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0034501 and protein localization to kinetochore and biological process this GO :0035173 and histone kinase activity and molecular function this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045471 and response to ethanol and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045931 and positive regulation of mitotic cell cycle and biological process this GO :0045995 and regulation of embryonic development and biological process this GO :0046686 and response to cadmium ion and biological process this GO :0046688 and response to copper ion and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048678 and response to axon injury and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0051437 and positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle and biological process this GO :0051439 and regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle and biological process this GO :0055015 and ventricular cardiac muscle cell development and biological process this GO :0060045 and positive regulation of cardiac muscle cell proliferation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0072686 and mitotic spindle and cellular component, cyclin-dependent kinase 1 |