| Long name: |
67) Monoclonal Antibody, 76, FZR (1621CT637 |
| Also known as: |
67) Monoclonal Antibody, 76, FZR (1621CT637 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FZR |
| Specificity: |
This is a highly specific antibody against FZR |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1621CT637, 67, 76 |
| Source: |
This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR |
| Gene ID number: |
51343 |
| Swiss Prot: |
Q9UM11 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:2000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Associates with the APC/C in late mitosis, At the G1/S transition FZR1 is phosphorylated, Following DNA damage, The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely, and activates the APC/C during anaphase and telophase, in replacement of CDC20, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, leading to its dissociation from the APC/C, preventing entry into mitosis, which confers substrate specificity upon the complex, Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C) |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CDC20-like protein 1, CDC20C, CDH1, Cdh1/Hct1 homolog, FYR, FZR1, FZR2, Fizzy-related protein homolog, HCDH, HCDH1, KIAA1242, FZR |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
67) Monoclonal, 76, FZR (1621CT637 |
| Short name: |
67) Monoclonal Antibody, 76, FZR (1621CT637 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
67) monoclonal (Antibody to), 76, FZR (1621CT637 |
| Alternative technique: |
antibodies |
| Identity: |
24824 |
| Gene: |
FZR1 |
More about : FZR1 |
| Long gene name: |
fizzy and cell division cycle 20 related 1 |
| Synonyms gene name: |
fizzy/cell division cycle 20 related 1 (Drosophila) fizzy/cell division cycle 20 related 1 |
| Synonyms: |
HCDH1 CDH1 HCDH FZR FZR2 KIAA1242 CDC20C |
| Synonyms name: |
CDC20 homolog 1 |
| Locus: |
19p13, 3 |
| Discovery year: |
2004-03-31 |
| GenBank acession: |
AF083810 |
| Entrez gene record: |
51343 |
| Pubmed identfication: |
9734353 11003657 |
| RefSeq identity: |
NM_016263 |
| Classification: |
WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000180747 |