| Long name: |
16) Monoclonal Antibody, 36, CDK2 (1534CT665 |
| Also known as: |
16) Monoclonal Antibody, 36, CDK2 (1534CT665 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CDK2 |
| Specificity: |
This is a highly specific antibody against CDK2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1534CT665, 16, 36 |
| Source: |
This CDK2 antibody is generated from a mouse immunized with protein from human CDK2 |
| Gene ID number: |
1017 |
| Swiss Prot: |
P24941 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:2000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activity of CDK2 is maximal during S phase and G2, Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, B1, B3, BRCA2, CDK7, Crucial role in orchestrating a fine balance between cellular proliferation, Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC, D, EZH2, EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing, In response to DNA damage, Interacts with cyclins A, Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis, MYC, NPAT, NPM1, Phosphorylates CABLES1 (By similarity), Phosphorylates CTNNB1, RB1, Triggers duplication of centrosomes and DNA, USP37, activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and DNA repair in human embryonic stem cells (hESCs), and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus, and modulates G2 progression, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, but dispensable for mitosis, but increases as cells progress towards mitosis, cell death, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation, essential for meiosis, or E, p53/TP53, regulates homologous recombination-dependent repair by phosphorylating BRCA2, the G2 phase, this phosphorylation is low in S phase when recombination is active, Serine/threonine-protein kinase involved in the control of the cell cycle |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CDK2, Cell division protein kinase 2, Cyclin-dependent kinase 2, p33 protein kinase, p33(CDK2), CDKN2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
16) Monoclonal, 36, CDK2 (1534CT665 |
| Short name: |
16) Monoclonal Antibody, 36, CDK2 (1534CT665 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
16) monoclonal (Antibody to), 36, CDK2 (1534CT665 |
| Alternative technique: |
antibodies |
| Identity: |
1771 |
| Gene: |
CDK2 |
More about : CDK2 |
| Long gene name: |
cyclin dependent kinase 2 |
| Locus: |
12q13, 2 |
| Discovery year: |
1992-02-28 |
| GenBank acession: |
M68520 |
| Entrez gene record: |
1017 |
| Pubmed identfication: |
1717994 8275715 |
| Classification: |
Cyclin dependent kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000170575 |