| Long name: |
1) Monoclonal Antibody, 13, HCK (1508CT602 |
| Also known as: |
1) Monoclonal Antibody, 13, HCK (1508CT602 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HCK |
| Specificity: |
This is a highly specific antibody against HCK |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 13, 1508CT602 |
| Source: |
This HCK antibody is generated from a mouse immunized with a recombinant protein of human HCK |
| Gene ID number: |
3055 |
| Swiss Prot: |
P08631 |
| Tested Applications: |
IF, WB |
| Recommended dilutions: |
WB(1:2000-1:4000), IF(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts downstream of receptors that bind the Fc region of immunoglobulins, BCR, During the phagocytic process, ELMO1, FCGR2A, GAB1, GAB2, IL2, IL6 and IL8, Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis, PLAUR, Phosphorylates ADAM15, Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors, Plays a role in the release of inflammatory molecules, Promotes reorganization of the actin cytoskeleton and actin polymerization, RAPGEF1, STAT5B, TP73, VAV1 and WAS, and activation of NADPH oxidase to bring about the respiratory burst, and integrins, but also CSF3R, cell adhesion and migration, cell survival and proliferation, degranulation, formation of podosomes and cell protrusions, including neutrophil, macrophage and mast cell functions, mediates mobilization of secretory lysosomes, monocyte, phagocytosis, such as FCGR1A and FCGR2A, such as ITGB1 and ITGB2, the receptors for IFNG, Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HCK, Hematopoietic cell kinase, Hemopoietic cell kinase, Tyrosine-protein kinase HCK, p59-HCK/p60-HCK, p59Hck, p61Hck, JTK9 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1) Monoclonal, 13, HCK (1508CT602 |
| Short name: |
1) Monoclonal Antibody, 13, HCK (1508CT602 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1) monoclonal (Antibody to), 13, hemopoietic cell kinase (1508CT602 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, HCK and IDBG-64463 and ENSG00000101336 and 3055, Hck and IDBG-209984 and ENSMUSG00000003283 and 15162, JTK9 and p59Hck and p61Hck, nuclei, this GO :0002522 and leukocyte migration involved in immune response and biological process this GO :0002758 and innate immune response-activating signal transduction and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005764 and lysosome and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005884 and actin filament and cellular component this GO :0005901 and caveola and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006909 and pha this GO cytosis and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007498 and mesoderm development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0016032 and viral process and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030133 and transport vesicle and cellular component this GO :0030838 and positive regulation of actin filament polymerization and biological process this GO :0031234 and extrinsic component of cytoplasmic side of plasma membrane and cellular component this GO :0031663 and lipopolysaccharide-mediated signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042995 and cell projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043299 and leukocyte degranulation and biological process this GO :0045087 and innate immune response and biological process this GO :0045728 and respiratory burst after pha this GO cytosis and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0050690 and regulation of defense response to virus by virus and biological process this GO :0050727 and regulation of inflammatory response and biological process this GO :0050764 and regulation of pha this GO cytosis and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0051090 and regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0071801 and regulation of podosome assembly and biological process this GO :2000251 and positive regulation of actin cytoskeleton reorganization and biological process, 44996 and IDBG-641612 and ENSBTAG00000007932 and 280814, hemopoietic cell kinase |
| Identity: |
4840 |
| Gene: |
HCK |
More about : HCK |
| Long gene name: |
HCK proto-oncogene, Src family tyrosine kinase |
| Synonyms gene name: |
hemopoietic cell kinase |
| Synonyms: |
JTK9 |
| Locus: |
20q11, 21 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AK026432 |
| Entrez gene record: |
3055 |
| Pubmed identfication: |
3496523 |
| Classification: |
SH2 domain containing Src family tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000032204 |