| Long name: |
2, 151, 34) Monoclonal Antibody, RPTOR (1411CT316 |
| Also known as: |
2, 151, 34) Monoclonal Antibody, RPTOR (1411CT316 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RPTOR |
| Specificity: |
This is a highly specific antibody against RPTOR |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1411CT316, 2, 34, 151 |
| Source: |
This RPTOR antibody is generated from a mouse immunized with recombinant protein |
| Gene ID number: |
57521 |
| Swiss Prot: |
Q8N122 |
| Tested Applications: |
IHC-P, WB |
| Recommended dilutions: |
WB(1:500-1:1000), IHC-P(1:25) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis, Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases, Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, Involved in ciliogenesis, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates, mTORC1 is activated in response to growth factors or amino acids, mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E), mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation, Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
KIAA1303, Mip1, RPTOR, Raptor, Regulatory-associated protein of mTOR, p150 target of rapamycin (TOR)-scaffold protein, KOG1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
2, 151, 34) Monoclonal, RPTOR (1411CT316 |
| Short name: |
2, 151, 34) Monoclonal Antibody, RPTOR (1411CT316 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
2, 151, 34) monoclonal (Antibody to), RPTOR (1411CT316 |
| Alternative technique: |
antibodies |
| Identity: |
30287 |
| Gene: |
RPTOR |
More about : RPTOR |
| Long gene name: |
regulatory associated protein of MTOR complex 1 |
| Synonyms gene name: |
complex 1 , regulatory associated protein of MTOR |
| Synonyms: |
KOG1 Mip1 KIAA1303 raptor |
| Synonyms name: |
regulatory associated protein of mTOR |
| Locus: |
17q25, 3 |
| Discovery year: |
2009-05-29 |
| Entrez gene record: |
57521 |
| Pubmed identfication: |
10718198 12150926 |
| RefSeq identity: |
NM_020761 |
| Classification: |
MTOR complex 1 WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000177622 |