| Long name: |
1, 12) Monoclonal Antibody, 6, ATG3 (1377CT239 |
| Also known as: |
1, 12) Monoclonal Antibody, 6, ATG3 (1377CT239 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ATG3 |
| Specificity: |
This is a highly specific antibody against ATG3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 1377CT239, 6, 12 |
| Source: |
This ATG3 antibody is generated from a mouse immunized with recombinant protein of human ATG3 |
| Gene ID number: |
64422 |
| Swiss Prot: |
Q9NT62 |
| Tested Applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:25), IHC-P(1:25) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy, ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3, Also acts as an autocatalytic E2-like enzyme, GABARAPL1, GABARAPL2 or MAP1LC3A), Preferred substrate is MAP1LC3A, Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway, Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE), The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt), This step is required for the membrane association of ATG8-like proteins, and mitochondrial homeostasis, autophagy, catalyzing the conjugation of ATG12 to itself, E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
APG3-LIKE, APG3L, ATG3, Autophagy-related protein 3, PC3-96, Protein PC3-96, Ubiquitin-like-conjugating enzyme ATG3, hApg3, APG3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1, 12) Monoclonal, 6, ATG3 (1377CT239 |
| Short name: |
1, 12) Monoclonal Antibody, 6, ATG3 (1377CT239 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1, 12) monoclonal (Antibody to), 6, autophagy related 3 (1377CT239 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ATG3 and IDBG-49891 and ENSG00000144848 and 64422, ATG3 and IDBG-632300 and ENSBTAG00000009084 and 508571, Atg3 and IDBG-162821 and ENSMUSG00000022663 and 67841, Cytoplasm, enzyme binding, this GO :0000045 and autophagic vacuole assembly and biological process this GO :0000153 and cytoplasmic ubiquitin ligase complex and cellular component this GO :0000422 and mitochondrion degradation and biological process this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006464 and cellular protein modification process and biological process this GO :0006612 and protein targeting to membrane and biological process this GO :0006914 and autophagy and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019776 and Atg8 ligase activity and molecular function this GO :0019777 and Atg12 ligase activity and molecular function this GO :0019787 and small conjugating protein ligase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0044804 and nucleophagy and biological process this GO :1902017 and regulation of cilium assembly and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0019776 : Atg8 ligase activity and also this GO :0019777 : Atg12 ligase activity and also this GO :0019787 : small conjugating protein ligase activity and also this GO :0019899 : enzyme binding, this GO :0019776 : Atg8 ligase activity, this GO :0019777 : Atg12 ligase activity, this GO :0019787 : small conjugating protein ligase activity, this GO :0019899 : enzyme binding, autophagy related 3 |
| Identity: |
20962 |
| Gene: |
ATG3 |
More about : ATG3 |
| Long gene name: |
autophagy related 3 |
| Synonyms gene: |
APG3L |
| Synonyms gene name: |
APG3 autophagy 3-like (S, cerevisiae) , cerevisiae) ATG3 autophagy related 3 homolog (S |
| Synonyms: |
PC3-96 FLJ22125 MGC15201 DKFZp564M1178 |
| Locus: |
3q13, 2 |
| Discovery year: |
2004-07-05 |
| Entrez gene record: |
64422 |
| Pubmed identfication: |
11825910 |
| RefSeq identity: |
NM_022488 |
| Classification: |
Autophagy related |
| Havana BLAST/BLAT: |
OTTHUMG00000159260 |