| Long name: |
1, 1) Monoclonal Antibody, VEGFR3 (818CT12 |
| Also known as: |
1, 1) Monoclonal Antibody, VEGFR3 (818CT12 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
VEGFR3 |
| Specificity: |
This is a highly specific antibody against VEGFR3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 1, 818CT12 |
| Source: |
Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody |
| Gene ID number: |
2324 |
| Swiss Prot: |
P35916 |
| Tested Applications: |
FCM, IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:25), FC(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, MAPK3/ERK1 signaling pathway, Mediates activation of the MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates KDR signaling by forming heterodimers, Phosphorylates SHC1, Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', Promotes proliferation, Signaling by activated FLT4 leads to enhanced production of VEGFC, The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis, and of AKT1 at 'Ser-473', and of the AKT1 signaling pathway, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development, and regulates angiogenic sprouting, and to a lesser degree VEGFA, because it has a truncated C-terminus and therefore lacks several phosphorylation sites, isoform 2 seems to be less efficient in signal transduction, of MAPK8 and the JUN signaling pathway, survival and migration of endothelial cells, the regulatory subunit of phosphatidylinositol 3-kinase, thereby creating a positive feedback loop that enhances FLT4 signaling, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FLT-4, FLT4, FLT41, Fms-like tyrosine kinase 4, LMPH1A, Tyrosine-protein kinase receptor FLT4, VEGFR-3, VEGFR3, Vascular endothelial growth factor receptor 3, PCL |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1, 1) Monoclonal, VEGFR3 (818CT12 |
| Short name: |
1, 1) Monoclonal Antibody, VEGFR3 (818CT12 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1, 1) monoclonal (Antibody to), VEGFR3 (818CT12 |
| Alternative technique: |
antibodies |
| Identity: |
3767 |
| Gene: |
FLT4 |
More about : FLT4 |
| Long gene name: |
fms related tyrosine kinase 4 |
| Synonyms gene name: |
fms-related tyrosine kinase 4 |
| Synonyms: |
VEGFR3 PCL |
| Locus: |
5q35, 3 |
| Discovery year: |
1991-10-25 |
| GenBank acession: |
X68203 |
| Entrez gene record: |
2324 |
| Pubmed identfication: |
1319394 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000130931 |