| Long name: |
5) Monoclonal Antibody, 7, PIN1 (855CT1 |
| Also known as: |
5) Monoclonal Antibody, 7, PIN1 (855CT1 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PIN1 |
| Specificity: |
This is a highly specific antibody against PIN1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
5, 7, 855CT1 |
| Source: |
Purified His-tagged PIN1 protein was used to produced this monoclonal antibody |
| Gene ID number: |
5300 |
| Swiss Prot: |
Q13526 |
| Tested Applications: |
FCM, IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:25), IHC-P(1:25) |
| Cross reactivity: |
Mouse, Other Species, Rat, Human |
| Cross reactive species details: |
African Green Monkey |
| Background of the target antigen: |
Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269), Can transactivate multiple oncogenes and induce centrosome amplification, Displays a preference for an acidic residue N-terminal to the isomerized proline bond, Down-regulates kinase activity of BTK (PubMed:16644721), PubMed:22033920), Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity, Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191), chromosome instability and cell transformation, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923), resulting in conformational changes in the proteins (PubMed:21497122, Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PIN1, PPIase Pin1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, Rotamase Pin1, UBL5, DOD |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
5) Monoclonal, 7, PIN1 (855CT1 |
| Short name: |
5) Monoclonal Antibody, 7, PIN1 (855CT1 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NIMA-interacting 1 (855CT1, 5) monoclonal (Antibody to), 7, peptidylprolyl cis/trans isomerase |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DOD and UBL5, NIMA-interacting 1, PIN1 and IDBG-26087 and ENSG00000127445 and 5300, PIN1 and IDBG-643081 and ENSBTAG00000016988 and 535470, nuclei, phosphothreonine binding, this GO :0000413 and protein peptidyl-prolyl isomerization and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0003755 and peptidyl-prolyl cis-trans isomerase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006457 and protein folding and biological process this GO :0007049 and cell cycle and biological process this GO :0007088 and regulation of mitosis and biological process this GO :0016607 and nuclear speck and cellular component this GO :0016853 and isomerase activity and molecular function this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030496 and midbody and cellular component this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0031434 and mitogen-activated protein kinase kinase binding and molecular function this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0032465 and regulation of cytokinesis and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0032794 and GTPase activating protein binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0050815 and phosphoserine binding and molecular function this GO :0050816 and phosphothreonine binding and molecular function this GO :0051443 and positive regulation of ubiquitin-protein transferase activity and biological process this GO :0060393 and regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0070373 and negative regulation of ERK1 and ERK2 cascade and biological process this GO :2000146 and negative regulation of cell motility and biological process, this GO :0003755 : peptidyl-prolyl cis-trans isomerase activity, this GO :0003755 : peptidyl-prolyl cis-trans isomerase activity and also this GO :0005515 : protein binding and also this GO :0016853 : isomerase activity and also this GO :0031434 : mitogen-activated protein kinase kinase binding and also this GO :0032794 : GTPase activating protein binding and also this GO :0050815 : phosphoserine binding and also this GO :0050816 : phosphothreonine binding, this GO :0005515 : protein binding, this GO :0016853 : isomerase activity, this GO :0031434 : mitogen-activated protein kinase kinase binding, this GO :0032794 : GTPase activating protein binding, this GO :0050815 : phosphoserine binding, this GO :0050816 : phosphothreonine binding, peptidylprolyl cis/trans isomerase |
| Identity: |
8988 |
| Gene: |
PIN1 |
More about : PIN1 |
| Long gene name: |
NIMA-interacting 1 , peptidylprolyl cis/trans isomerase |
| Synonyms gene name: |
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 |
| Synonyms: |
dod |
| Locus: |
19p13 |
| Discovery year: |
1996-12-16 |
| Entrez gene record: |
5300 |
| Pubmed identfication: |
8606777 |
| Classification: |
Parvulins |
| Havana BLAST/BLAT: |
OTTHUMG00000180388 |
| Locus Specific Databases: |
LRG_847 |