| Long name: |
11, 4) Monoclonal Antibody, PODXL (632CT5 |
| Also known as: |
11, 4) Monoclonal Antibody, PODXL (632CT5 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PODXL |
| Specificity: |
This is a highly specific antibody against PODXL |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
4, 11, 632CT5 |
| Source: |
This PODXL antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human PODXL |
| Gene ID number: |
5420 |
| Swiss Prot: |
O00592 |
| Tested Applications: |
IF, WB |
| Recommended dilutions: |
WB(1:500-5000), IF(1:100) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a pro-adhesive molecule, Affects EZR-dependent signaling events, Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion, Induces the formation of apical actin-dependent microvilli, Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis, Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner, leading to increased activities of the MAPK and PI3K pathways in cancer cells, Involved in the regulation of both adhesion and cell morphology and cancer progression |
| Purification method: |
09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
GCTM-2 antigen, Gp200, PCLP, PCLP-1, PCLP1, PODXL, Podocalyxin, Podocalyxin-like protein 1, PC |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
11, 4) Monoclonal, PODXL (632CT5 |
| Short name: |
11, 4) Monoclonal Antibody, PODXL (632CT5 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
11, 4) monoclonal (Antibody to), podocalyxin-like (632CT5 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, Gp200 and PC and PCLP and PCLP-1, PODXL and IDBG-41798 and ENSG00000128567 and 5420, PODXL and IDBG-635552 and ENSBTAG00000010452 and 616366, Podxl and IDBG-133888 and ENSMUSG00000025608 and 27205, protein binding, this GO :0001726 and ruffle and cellular component this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0016324 and apical plasma membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0022408 and negative regulation of cell-cell adhesion and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030175 and filopodium and cellular component this GO :0030335 and positive regulation of cell migration and biological process this GO :0031528 and microvillus membrane and cellular component this GO :0032534 and regulation of microvillus assembly and biological process this GO :0033634 and positive regulation of cell-cell adhesion mediated by integrin and biological process this GO :0036057 and slit diaphragm and cellular component this GO :0044297 and cell body and cellular component this GO :0045121 and membrane raft and cellular component this GO :0050900 and leukocyte migration and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0072015 and glomerular visceral epithelial cell development and biological process this GO :0072175 and epithelial tube formation and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, podocalyxin-like |
| Identity: |
9171 |
| Gene: |
PODXL |
More about : PODXL |
| Long gene name: |
podocalyxin like |
| Synonyms gene name: |
podocalyxin-like |
| Synonyms: |
PCLP Gp200 PC |
| Locus: |
7q32, 3 |
| Discovery year: |
1997-07-11 |
| Entrez gene record: |
5420 |
| RefSeq identity: |
NM_001018111 |
| Havana BLAST/BLAT: |
OTTHUMG00000154918 |