| Long name: |
2, 2) Monoclonal Antibody, RUVBL1 (507CT2 |
| Also known as: |
2, 2) Monoclonal Antibody, RUVBL1 (507CT2 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RUVBL1 |
| Specificity: |
This is a highly specific antibody against RUVBL1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
2, 2, 507CT2 |
| Source: |
Purified His-tagged RUVBL1 protein(Fragment) was used to produced this monoclonal antibody |
| Gene ID number: |
8607 |
| Swiss Prot: |
Q9Y265 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:100~500) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Component of a SWR1-like complex that specifically mediates the removal of histone H2A, Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A, DNA replication and probably DNA repair, Essential for cell proliferation, May be able to bind plasminogen at cell surface and enhance plasminogen activation, NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage, Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex, Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, The NuA4 complex ATPase and helicase activities seem to be, This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription, and DNA repair, apoptosis, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400, hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity, tumor suppressor mediated growth arrest and replicative senescence, Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity, Z/H2AFZ from the nucleosome |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, ECP54, INO80 complex subunit H, INO80H, NMP 238, NMP238, Nuclear matrix protein 238, PONTIN, Pontin 52, Pontin52, RUVBL1, RuvB-like 1, TAP54-alpha, TIH1, TIP49, TIP49A, TIP60-associated protein 54-alpha, RVB1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
2, 2) Monoclonal, RUVBL1 (507CT2 |
| Short name: |
2, 2) Monoclonal Antibody, RUVBL1 (507CT2 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
2, 2) monoclonal (Antibody to), RUVBL1 (507CT2 |
| Alternative technique: |
antibodies |
| Identity: |
10474 |
| Gene: |
RUVBL1 |
More about : RUVBL1 |
| Long gene name: |
RuvB like AAA ATPase 1 |
| Synonyms gene name: |
RuvB (E coli homolog)-like 1 RuvB-like 1 (E, coli) RuvB-like AAA ATPase RuvB-like AAA ATPase 1 |
| Synonyms: |
TIP49 NMP238 RVB1 TIP49a Pontin52 ECP54 TIH1 Rvb1 INO80H |
| Synonyms name: |
pontin INO80 complex subunit H |
| Locus: |
3q21, 3 |
| Discovery year: |
1998-11-19 |
| GenBank acession: |
AF070735 |
| Entrez gene record: |
8607 |
| Pubmed identfication: |
9774387 9588198 |
| Classification: |
AAA ATPases INO80 complex DNA helicases SRCAP complex |
| Havana BLAST/BLAT: |
OTTHUMG00000159658 |