| Long name: |
1, 2) Monoclonal Antibody, 6, RPS6KA3 (356CT10 |
| Also known as: |
1, 2) Monoclonal Antibody, 6, RPS6KA3 (356CT10 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RPS6KA3 |
| Specificity: |
This is a highly specific antibody against RPS6KA3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 2, 356CT10, 6 |
| Source: |
Purified His-tagged RPS6KA3 protein(Fragment) was used to produced this monoclonal antibody |
| Gene ID number: |
6197 |
| Swiss Prot: |
P51812 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:100~500) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ETV1/ER81 and NR4A1/NUR77, In fibroblast, In response to insulin, In response to mitogenic stimulation (EGF and PMA), Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', Mediates cell survival by phosphorylating the pro-apoptotic proteins, Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex, Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1, and mediates cellular proliferation, and mediates phosphorylation of RPTOR, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', phosphorylates EIF4B, phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP, regulates translation through RPS6 and EIF4B phosphorylation, survival, which potently inhibits TSC2 ability to suppress mTOR signaling, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway, which results in the subsequent transcriptional activation of several immediate-early genes, Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1 |
| Purification method: |
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
90 kDa ribosomal protein S6 kinase 3, HU-3, ISPK-1, ISPK1, Insulin-stimulated protein kinase 1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, MAPKAPK1B, MRX19, RPS6KA3, RSK, RSK-2, RSK2, Ribosomal S6 kinase 2, Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, S6K-alpha3, p90-RSK 3, p90-RSK2, p90RSK3, pp90RSK2, CLS |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1, 2) Monoclonal, 6, RPS6KA3 (356CT10 |
| Short name: |
1, 2) Monoclonal Antibody, 6, RPS6KA3 (356CT10 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
90kDa, polypeptide 3 (356CT10, 1, 2) monoclonal (Antibody to), 6, ribosomal protein S6 phosphorylation catalyst |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
90kDa, CLS and HU-3 and ISPK-1 and MAPKAPK1B and MRX19 and p90-RSK2 and pp90RSK2 and RSK and RSK2 and S6K-alpha3, RPS6KA3 and IDBG-50812 and ENSG00000177189 and 102724381, RPS6KA3 and IDBG-638536 and ENSBTAG00000017639 and 511190, Rps6ka3 and IDBG-182115 and ENSMUSG00000031309 and 110651, alcohol group as acceptor, alcohol group as acceptor and also this GO :0019901 : protein kinase binding and also this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process, alcohol group as acceptor and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030307 and positive regulation of cell growth and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043027 and cysteine-type endopeptidase inhibitor activity involved in apoptotic process and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043154 and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043555 and regulation of translation in response to stress and biological process this GO :0043620 and regulation of DNA-dependent transcription in response to stress and biological process this GO :0045087 and innate immune response and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051403 and stress-activated MAPK cascade and biological process, nuclei, polypeptide 3, this GO :0000287 and magnesium ion binding and molecular function this GO :0001501 and skeletal system development and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005840 and ribosome and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007049 and cell cycle and biological process this GO :0007165 and signal transduction and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007411 and axon guidance and biological process this GO :0007417 and central nervous system development and biological process this GO :0009103 and lipopolysaccharide biosynthetic process and biological process this GO :0016020 and membrane and cellular component this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0016773 : phosphotransferase activity, this GO :0019901 : protein kinase binding, this GO :0043027 : cysteine-type endopeptidase inhibitor activity involved in apoptotic process, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773 : phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, 6197, ribosomal protein S6 kinase |
| Identity: |
10432 |
| Gene: |
RPS6KA3 |
More about : RPS6KA3 |
| Long gene name: |
ribosomal protein S6 kinase A3 |
| Synonyms gene: |
MRX19 CLS |
| Synonyms gene name: |
90kD, polypeptide 3 , ribosomal protein S6 kinase |
| Synonyms: |
RSK RSK2 HU-3 |
| Locus: |
Xp22, 12 |
| Discovery year: |
1994-07-11 |
| GenBank acession: |
U08316 |
| Entrez gene record: |
6197 |
| Pubmed identfication: |
8141249 11896450 16879200 |
| RefSeq identity: |
NM_004586 |
| Classification: |
X-linked mental retardation Mitogen-activated protein kinase-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000021231 |
| Locus Specific Databases: |
Mental Retardation database |