| Long name: |
1) Monoclonal Antibody, 6, MYOG (304CT11 |
| Also known as: |
1) Monoclonal Antibody, 6, MYOG (304CT11 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MYOG |
| Specificity: |
This is a highly specific antibody against MYOG |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1, 304CT11, 6 |
| Source: |
This MYOG antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 30-58 amino acids from the N-terminal region of human MYOG |
| Gene ID number: |
4656 |
| Swiss Prot: |
P15173 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:1000~4000) |
| Cross reactivity: |
Mouse |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binds to the E-box containing (E1) promoter region of the miR-20a gene, Contributes to the atrophy-related gene expression in adult denervated muscles, Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters, During terminal myoblast differentiation, Essential for the development of functional embryonic skeletal fiber muscle differentiation, Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, However is dispensable for postnatal skeletal muscle growth, Induces fibroblasts to differentiate into myoblasts (By similarity), Plays also a role in preventing reversal of muscle cell differentiation, Required for the recruitment of the FACT complex to muscle-specific promoter regions, Together with MYF5 and MYOD1, cell cycle exit and muscle atrophy, co-occupies muscle-specific gene promoter core regions during myogenesis, phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1, thus promoting gene expression initiation, which in turn represses genes involved in cell cycle progression, Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation |
| Purification method: |
09% (W/V) sodium azide, Mouse monoclonal antibody supplied in crude ascites with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Class C basic helix-loop-helix protein 3, MYOG, Myogenic factor 4, Myogenin, bHLHc3, myf-4, MYF4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
1) Monoclonal, 6, MYOG (304CT11 |
| Short name: |
1) Monoclonal Antibody, 6, MYOG (304CT11 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
1) monoclonal (Antibody to), 6, MYOG (304CT11 |
| Alternative technique: |
antibodies |
| Identity: |
7612 |
| Gene: |
MYOG |
More about : MYOG |
| Long gene name: |
myogenin |
| Synonyms gene: |
MYF4 |
| Synonyms gene name: |
myogenin (myogenic factor 4) |
| Synonyms: |
bHLHc3 |
| Synonyms name: |
myogenic factor 4 |
| Locus: |
1q32, 1 |
| Discovery year: |
1990-11-20 |
| GenBank acession: |
BC053899 |
| Entrez gene record: |
4656 |
| Pubmed identfication: |
10329008 |
| RefSeq identity: |
NM_002479 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000042127 |