| Long name: |
2, 4) Monoclonal Antibody, RYK (240CT2 |
| Also known as: |
2, 4) Monoclonal Antibody, RYK (240CT2 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RYK |
| Specificity: |
This is a highly specific antibody against RYK |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
2, 240CT2, 4 |
| Source: |
This RYK monoclonal antibody is generated from mouse immunized with RYK recombinant protein |
| Gene ID number: |
6259 |
| Swiss Prot: |
P34925 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:100~500) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
In response to WNT3 stimulation, Involved in neuron differentiation, WNT3, WNT3A and WNT5A, axon guidance, corpus callosum establishment and neurite outgrowth, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development, such as WNT1, May be a coreceptor along with FZD8 of Wnt proteins |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
D3S3195, JTK5A, RYK, RYK1, Tyrosine-protein kinase RYK, JTK5 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
2, 4) Monoclonal, RYK (240CT2 |
| Short name: |
2, 4) Monoclonal Antibody, RYK (240CT2 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
2, 4) monoclonal (Antibody to), receptor-like tyrosine kinase (240CT2 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
D3S3195 and JTK5 and JTK5A and RYK1, RYK and IDBG-57467 and ENSG00000163785 and 6259, RYK and IDBG-638818 and ENSBTAG00000016999 and 781353, Ryk and IDBG-194079 and ENSMUSG00000032547 and 20187, nuclei, this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005109 and frizzled binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007409 and axonogenesis and biological process this GO :0007411 and axon guidance and biological process this GO :0016020 and membrane and cellular component this GO :0016055 and Wnt signaling pathway and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005109 : frizzled binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005109 : frizzled binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0017147 : Wnt-protein binding, this GO :0042813 : Wnt-activated receptor activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017147 : Wnt-protein binding and also this GO :0042813 : Wnt-activated receptor activity, transferring phosphorus-containing groups and molecular function this GO :0017147 and Wnt-protein binding and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0022038 and corpus callosum development and biological process this GO :0030182 and neuron differentiation and biological process this GO :0031175 and neuron projection development and biological process this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0048705 and skeletal system morphogenesis and biological process this GO :0048843 and negative regulation of axon extension involved in axon guidance and biological process this GO :0050919 and negative chemotaxis and biological process this GO :0071679 and commissural neuron axon guidance and biological process, receptor-like tyrosine kinase |
| Identity: |
10481 |
| Gene: |
RYK |
More about : RYK |
| Long gene name: |
receptor-like tyrosine kinase |
| Synonyms gene: |
JTK5A |
| Synonyms gene name: |
JTK5A protein tyrosine kinase RYK receptor-like tyrosine kinase |
| Synonyms: |
D3S3195 RYK1 JTK5 |
| Locus: |
3q22, 2 |
| Discovery year: |
1993-09-28 |
| GenBank acession: |
S59184 |
| Entrez gene record: |
6259 |
| Pubmed identfication: |
8386829 |
| RefSeq identity: |
NM_001005861 |
| Classification: |
Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000159750 |