| Long name: |
3) Monoclonal Antibody, 5, ELAVL1 (224CT6 |
| Also known as: |
3) Monoclonal Antibody, 5, ELAVL1 (224CT6 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ELAVL1 |
| Specificity: |
This is a highly specific antibody against ELAVL1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
224CT6, 3, 5 |
| Source: |
This ELAVL1 monoclonal antibody is generated from mouse immunized with ELAVL1 recombinant protein |
| Gene ID number: |
1994 |
| Swiss Prot: |
Q15717 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AUUUUA, Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs, Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503), Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, Hence, In the case of the FOS AU-rich element, Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), May also bind with ZNF385A the CCNB1 mRNA (By similarity), PubMed:17632515, PubMed:18285462, PubMed:18285462), PubMed:23519412), With ZNF385A, and AUUUUUA motifs, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A, binds to a core element of 27 nucleotides that contain AUUUA, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity, promoting ESCs differentiation (By similarity), stabilizing them, RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288 |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ELAV-like protein 1, ELAV1, ELAVL1, Hu-antigen R, Hua, MelG, HUR |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
3) Monoclonal, 5, ELAVL1 (224CT6 |
| Short name: |
3) Monoclonal Antibody, 5, ELAVL1 (224CT6 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
3) monoclonal (Antibody to), 5, ELAVL1 (224CT6 |
| Alternative technique: |
antibodies |
| Identity: |
3312 |
| Gene: |
ELAVL1 |
More about : ELAVL1 |
| Long gene name: |
ELAV like RNA binding protein 1 |
| Synonyms gene: |
HUR |
| Synonyms gene name: |
Drosophila)-like 1 (Hu antigen R) , ELAV (embryonic lethal, abnormal vision |
| Synonyms: |
HuR Hua MelG |
| Synonyms name: |
abnormal vision, drosophila, embryonic lethal, homolog-like 1 Hu antigen R |
| Locus: |
19p13, 2 |
| Discovery year: |
1996-08-12 |
| GenBank acession: |
U38175 |
| Entrez gene record: |
1994 |
| Pubmed identfication: |
8626503 9003489 |
| RefSeq identity: |
NM_001419 |
| Classification: |
RNA binding motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000182470 |