| Long name: |
2, 3) Monoclonal Antibody, PDK2 (180CT10 |
| Also known as: |
2, 3) Monoclonal Antibody, PDK2 (180CT10 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PDK2 |
| Specificity: |
This is a highly specific antibody against PDK2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
180CT10, 2, 3 |
| Source: |
This PDK2 monoclonal antibody is generated from mouse immunized with PDK2 recombinant protein |
| Gene ID number: |
5164 |
| Swiss Prot: |
Q15119 |
| Tested Applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:25-100), WB(1:1000) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism, Mediates cellular responses to insulin, Plays a role in p53/TP53-mediated apoptosis, Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress, Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability, This inhibits pyruvate dehydrogenase activity, Via its regulation of pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation, Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PDH kinase 2, PDK2, PDKII, Pyruvate dehydrogenase kinase isoform 2, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, PDHK2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
2, 3) Monoclonal, PDK2 (180CT10 |
| Short name: |
2, 3) Monoclonal Antibody, PDK2 (180CT10 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
2, 3) monoclonal (Antibody to), PDK2 (180CT10 |
| Alternative technique: |
antibodies |
| Identity: |
8810 |
| Gene: |
PDK2 |
More about : PDK2 |
| Long gene name: |
pyruvate dehydrogenase kinase 2 |
| Synonyms gene name: |
isoenzyme 2 pyruvate dehydrogenase kinase, isozyme 2 , pyruvate dehydrogenase kinase |
| Synonyms: |
PDHK2 |
| Locus: |
17q21, 33 |
| Discovery year: |
1996-08-14 |
| GenBank acession: |
L42451 |
| Entrez gene record: |
5164 |
| Pubmed identfication: |
7499431 |
| RefSeq identity: |
NM_002611 |
| Havana BLAST/BLAT: |
OTTHUMG00000161948 |