| Long name: |
MET/HGFR (4AT44) Monoclonal Antibody |
| Also known as: |
MET/HGFR (4AT44) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MET/HGFR |
| Specificity: |
This is a highly specific antibody against MET/HGFR |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
4AT44 |
| Source: |
This monoclonal antibody is generated from mice immunized with purified recombinant protein encoding the catalytic domain of human Met |
| Gene ID number: |
4233 |
| Swiss Prot: |
P08581 |
| Tested Applications: |
IF, IHC-P, WB |
| Recommended dilutions: |
WB(1:1000), IF(1:100), IHC-P(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a receptor for Listeria internalin inlB, During embryonic development, Following activation by ligand, GRB2, In adults, Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules, MET signaling plays a role in gastrulation, PI3 kinase-AKT, PLCG1, Promotes also differentiation and proliferation of hematopoietic cells, Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, Regulates many physiological processes including proliferation, SRC, STAT3 or the adapter GAB1, The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects, angiogenesis and kidney formation, development and migration of muscles and neuronal precursors, interacts with the PI3-kinase subunit PIK3R1, mediating entry of the pathogen into cells, morphogenesis and survival, or PLCgamma-PKC, participates in wound healing as well as organ regeneration and tissue remodeling, scattering, Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
AUTS9, DFNB97, HGF receptor, HGF/SF receptor, Hepatocyte growth factor receptor, MET, Proto-oncogene c-Met, RCCP2, SF receptor, Scatter factor receptor, Tyrosine-protein kinase Met, c-Met, HGFR |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
MET/HGFR (4AT44) Monoclonal |
| Short name: |
MET/HGFR (4AT44) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MET/HGFR (4AT44) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
20709 |
| Gene: |
SLTM |
More about : SLTM |
| Long gene name: |
SAFB like transcription modulator |
| Synonyms: |
Met FLJ13213 |
| Locus: |
15q22, 1 |
| Discovery year: |
2005-11-08 |
| GenBank acession: |
BC046119 |
| Entrez gene record: |
79811 |
| RefSeq identity: |
NM_024755 |
| Classification: |
RNA binding motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000074033 |