| Long name: |
TCPTP (T25-AF3B7) Monoclonal Antibody |
| Also known as: |
TCPTP (T25-AF3B7) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TCPTP |
| Specificity: |
This is a highly specific antibody against TCPTP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
T25-AF3B7 |
| Source: |
Recombinant human protein purified from E, coli |
| Gene ID number: |
5771 |
| Swiss Prot: |
P17706 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB (1:2000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activated by the integrin ITGA1/ITGB1, Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively, CSF1R, Dephosphorylates CSF1R, Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation, EGFR, Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation, In addition to the immune system, JAK2, JAK3, JAK3 and their substrate STAT1, May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET, Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation, PDGFR, Plays a multifaceted and important role in the development of the immune system, Plays also an important role in glucose homeostasis, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm, Src family kinases, and glucose homeostasis, cell proliferation and differentiation, inflammatory response, it dephosphorylates EGFR and negatively regulates EGF signaling, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth, negatively regulating its downstream signaling and macrophage differentiation, that propagate signaling downstream of the cytokine receptors, Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR |
| Purification method: |
Ammonium sulfate precipitation |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PTPN2, PTPT, T-cell protein-tyrosine phosphatase, TC-PTP, TCELLPTP, TCPTP, Tyrosine-protein phosphatase non-receptor type 2, PTN2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
TCPTP (T25-AF3B7) Monoclonal |
| Short name: |
TCPTP (T25-AF3B7) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TCPTP (T25-AF3B7) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9650 |
| Gene: |
PTPN2 |
More about : PTPN2 |
| Long gene name: |
non-receptor type 2 , protein tyrosine phosphatase |
| Synonyms gene: |
PTPT |
| Synonyms: |
TCELLPTP TC-PTP TCPTP |
| Locus: |
18p11, 21 |
| Discovery year: |
1991-09-13 |
| GenBank acession: |
M25393 |
| Entrez gene record: |
5771 |
| Pubmed identfication: |
2164224 |
| RefSeq identity: |
NM_002828 NM_080422 NM_080423 |
| Classification: |
Protein tyrosine phosphatases, non-receptor type |
| Havana BLAST/BLAT: |
OTTHUMG00000131702 |