| Long name: |
PP1B (AF9B12) Monoclonal Antibody |
| Also known as: |
PP1B (AF9B12) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PP1B |
| Specificity: |
This is a highly specific antibody against PP1B |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
AF9B12 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant human protein purified from E, coli (His-PP1B) |
| Gene ID number: |
5500 |
| Swiss Prot: |
P62140 |
| Tested Applications: |
WB |
| Recommended dilutions: |
2 ug/ml), WB (0 |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Component of the PTW/PP1 phosphatase complex, Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, In balance with CSNK1D and CSNK1E, Involved in regulation of ionic conductances and long-term synaptic plasticity, May dephosphorylate CSNK1D and CSNK1E, Protein phosphatase (PP1) is essential for cell division, determines the circadian period length, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208), through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HEL-S-80p, PP-1B, PP1beta, PPP1CB, PPP1CD, Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP1B |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
PP1B (AF9B12) Monoclonal |
| Short name: |
PP1B (AF9B12) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PP1B (AF9B12) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9282 |
| Gene: |
PPP1CB |
More about : PPP1CB |
| Long gene name: |
protein phosphatase 1 catalytic subunit beta |
| Synonyms gene name: |
beta isoform protein phosphatase 1, beta isozyme , catalytic subunit, catalytic subunit, protein phosphatase 1 |
| Synonyms: |
PP1B PP-1B PP1beta |
| Locus: |
2p23, 2 |
| Discovery year: |
1993-01-22 |
| Entrez gene record: |
5500 |
| Pubmed identfication: |
8312365 |
| Classification: |
Protein phosphatase catalytic subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000152011 |