| Long name: |
FAK1 (1D10) Monoclonal Antibody |
| Also known as: |
FAK1 (1D10) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FAK1 |
| Specificity: |
This is a highly specific antibody against FAK1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1D10 |
| Concentration: |
2ug/ul |
| Source: |
1-421 a, ), Recombinant human protein purified from E, a, coli(His-FAK1 |
| Gene ID number: |
5747 |
| Swiss Prot: |
Q05397 |
| Tested Applications: |
IP, WB |
| Recommended dilutions: |
0 ug), 0 ug/mL) IP (2, WB (2 |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
FAK is a nonreceptor and nonmembrane associated PTK which does not contain Src homology 2 (SH2) or SH3 protein interaction domains, FAK links integrin receptors to intracellular signaling pathways that are important for cell growth, Integrin receptor engagement with ligands such as fibronectin can stimulate FAK autophosphorylation which enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways, Recent study reveals that FAK is essential for angiogenesis in the embryo, The centrally located kinase domain of FAK is flanked by large N- and C-terminal noncatalytic domains, The presence of two proline-rich motifs within the C-terminal domains is conserved, These two kinases have molecular mass between 110-125 kDa and are closely related in their structure, Two members of the family are focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2), and migration, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice, survival, Focal adhesion kinase subfamily consists of the non-receptor proline-rich protein tyrosine kinases (PTKs) |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FADK, FADK 1, FAK1, FRNK, Focal adhesion kinase 1, Focal adhesion kinase-related nonkinase, PPP1R71, PTK2, Protein phosphatase 1 regulatory subunit 71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FAK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
FAK1 (1D10) Monoclonal |
| Short name: |
FAK1 (1D10) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FAK1 (1D10) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9611 |
| Gene: |
PTK2 |
More about : PTK2 |
| Long gene name: |
protein tyrosine kinase 2 |
| Synonyms gene name: |
PTK2 protein tyrosine kinase 2 |
| Synonyms: |
FAK FADK FAK1 PPP1R71 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 71 |
| Locus: |
8q24, 3 |
| Discovery year: |
1992-10-02 |
| GenBank acession: |
L13616 |
| Entrez gene record: |
5747 |
| Pubmed identfication: |
8422239 |
| RefSeq identity: |
NM_005607 |
| Classification: |
Protein phosphatase 1 regulatory subunits FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000067438 |