| Long name: |
RIP1 (7H10) Monoclonal Antibody |
| Also known as: |
RIP1 (7H10) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RIP1 |
| Specificity: |
This is a highly specific antibody against RIP1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
7H10 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant human protein purified from E, coli (His/ABD-RIP1) |
| Gene ID number: |
8737 |
| Swiss Prot: |
Q13546 |
| Tested Applications: |
IP, WB |
| Recommended dilutions: |
000) IP (2 ul), WB (1:500~1:2 |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death, Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, Polyubiquitinated protein binds to IKBKG/NEMO, RIPK1 and RIPK3 association, TRADD and TRAF2 are recruited to the receptor, Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, Upon activation of TNFR1 by the TNF-alpha family cytokines, a critical event for NF-kappa-B activation, activation of pathogen recognition receptors (PRRs), and DNA damage, and thereby activates the MAP3K5-JNK apoptotic cascade, forms a necrosis-inducing complex, in particular, the regulatory subunit of the IKK complex, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules, Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Cell death protein RIP, RIP-1, RIP1, RIPK1, Receptor-interacting protein 1, Receptor-interacting serine/threonine-protein kinase 1, Serine/threonine-protein kinase RIP, RIP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
RIP1 (7H10) Monoclonal |
| Short name: |
RIP1 (7H10) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RIP1 (7H10) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9841 |
| Gene: |
RALBP1 |
More about : RALBP1 |
| Long gene name: |
ralA binding protein 1 |
| Synonyms: |
RLIP76 RIP1 RIP |
| Locus: |
18p11, 22 |
| Discovery year: |
2000-02-11 |
| GenBank acession: |
L42542 |
| Entrez gene record: |
10928 |
| Pubmed identfication: |
7673236 |
| RefSeq identity: |
NM_006788 |
| Havana BLAST/BLAT: |
OTTHUMG00000131596 |