| Long name: |
(27H4) Monoclonal Antibody, Casein Kinase II &alpha |
| Also known as: |
(27H4) Monoclonal Antibody, Casein Kinase II &alpha |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Casein Kinase II &alpha |
| Specificity: |
This is a highly specific antibody against Casein Kinase II &alpha |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
27H4 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant human protein purified from E, coli(His-Casein kinase II a) |
| Gene ID number: |
1457 |
| Swiss Prot: |
P68400 |
| Tested Applications: |
WB |
| Recommended dilutions: |
5ug/mL), WB (0 |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ATF1, Acts as an ectokinase that phosphorylates several extracellular proteins, Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, Also required for p53/TP53-mediated apoptosis, CMV and HPV, CREB1, Can also negatively regulate apoptosis, During mitosis, During viral infection, FOS, HBV, HCV, HIV, HSV, II, III and IV, IRF1, IRF2, JUN, MAX, MYC and MYB, May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response, Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation, Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3, Phosphorylation protects CASP9 from cleavage and activation by CASP8, Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1, Regulates numerous cellular processes, Regulates transcription by direct phosphorylation of RNA polymerases I, SRF, STAT1, and inhibits the dimerization of CASP2 and activation of CASP8, apoptosis and transcription, as well as viral infection, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage, phosphorylates various proteins involved in the viral life cycles of EBV, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation, such as cell cycle progression, which is essential for chaperone function, Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CK II alpha, CK2A1, CSNK2A1, CSNK2A3, Casein kinase II subunit alpha, OCNDS, CKII |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
(27H4) Monoclonal, Casein Kinase II &alpha |
| Short name: |
(27H4) Monoclonal Antibody, Casein Kinase II &alpha |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
(27H4) monoclonal (Antibody to), Casein phosphorylation catalyst II &alpha |
| Alternative technique: |
antibodies |