| Long name: |
Erk1/2 (3A1) Monoclonal Antibody |
| Also known as: |
Erk1/2 (3A1) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Erk1/2 |
| Specificity: |
This is a highly specific antibody against Erk1/2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
3A1 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant human protein purified from E, coli |
| Gene ID number: |
5595 |
| Swiss Prot: |
P27361 |
| Tested Applications: |
WB |
| Recommended dilutions: |
1 ug/ml), WB (0 |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
About 160 substrates have already been discovered for ERKs, Depending on the cellular context, However, MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade, Many of these substrates are localized in the nucleus, Moreover, The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF, adhesion, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors, and seem to participate in the regulation of transcription upon stimulation, and those are responsible for processes such as translation, as well as in the fragmentation of the Golgi apparatus during mitosis, cytoskeletal rearrangements, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), mitosis, mitosis and apoptosis, other substrates are found in the cytosol as well as in other cellular organelles, survival and differentiation through the regulation of transcription, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, translation, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ERK-1, ERT2, Extracellular signal-regulated kinase 1, HS44KDAP, HUMKER1A, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, MAPK3, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 3, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, ERK1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
Erk1/2 (3A1) Monoclonal |
| Short name: |
Erk1/2 (3A1) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Erk1/2 (3A1) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |