| Long name: |
CDK6 (75B9) Monoclonal Antibody |
| Also known as: |
CDK6 (75B9) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CDK6 |
| Specificity: |
This is a highly specific antibody against CDK6 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
75B9 |
| Source: |
Recombinant human protein purified from E, coli |
| Gene ID number: |
1021 |
| Swiss Prot: |
Q00534 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB (1:500) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Delays senescence, Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles, Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle, Involved in initiation and maintenance of cell cycle exit during cell differentiation, May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663), Phosphorylates pRB/RB1 and NPM1, Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, Promotes, Promotes the production of newborn neurons, Promotes the proliferation of beta-cells in pancreatic islets of Langerhans, Required during thymocyte development, and enhanced motility during cell differentiation, at least in astrocytes, but is required for the proliferation of specific cell types (e, but promotes proliferation of normal myeloid progenitors, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, erythroid and hematopoietic cells), prevents cell proliferation and regulates negatively cell differentiation, probably by modulating G1 length, promotes G1/S transition, Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, g |
| Purification method: |
Ammonium sulfate precipitation |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CDK6, CDKN6, Cell division protein kinase 6, Cyclin-dependent kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE, MCPH12 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
CDK6 (75B9) Monoclonal |
| Short name: |
CDK6 (75B9) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CDK6 (75B9) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1777 |
| Gene: |
CDK6 |
More about : CDK6 |
| Long gene name: |
cyclin dependent kinase 6 |
| Synonyms: |
PLSTIRE |
| Locus: |
7q21, 2 |
| Discovery year: |
1994-02-14 |
| Entrez gene record: |
1021 |
| Pubmed identfication: |
1639063 |
| Classification: |
Cyclin dependent kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000131697 |
| Locus Specific Databases: |
LRG_991 |