| Also known as: |
NF-L / NEFL |
| Other names: |
68 kDa neurofilament protein, Neurofilament light polypeptide, Neurofilament triplet L protein, light chain, light molecular weight neurofilament protein, light polypeptide, light polypeptide 68kDa, neurofilament, neurofilament, neurofilament light polypeptide, neurofilament protein, neurofilament subunit NF-L, neurofilament triplet L protein, protein phosphatase 1, regulatory subunit 110, neurofilament light polypeptide |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
NF-L |
| Gene name synonims: |
NEFL |
| Other gene names: |
CMT1F, CMT2E, NEFL, NF-L, NF-L, NF68, NF68, NFL, NFL, PPP1R110, NEFL |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
2F11 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, Opossum, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Reacts exclusively with the phosphorylated isoform of the70 kD neurofilament protein |
| Purification method: |
Purified |
| Form/Appearance: |
Sourced in TCS, 09% sodium azide, PBS containing 0 |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store undiluted, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
IHC - Frozen), Western Blot (WB), Immunohistochemistry (IHC - Paraffin |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 2F11] (IgG1) NF-L / NEFL |
| Short name: |
Mouse Monoclonal [clone 2F11] (IgG1) NF-L / NEFL Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
light polypeptide (Antibody to), sapiens NF-L / neurofilament, Mouse monoclonal [clonality 2F11] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CMT1F and CMT2E and NF-L and NF68 and NFL and PPP1R110, Cytoplasm, NEFL and IDBG-635366 and ENSBTAG00000021949 and 281348, NEFL and IDBG-777808 and ENSG00000277586 and 4747, Nefl and IDBG-176493 and ENSMUSG00000022055 and 18039, bridging, bridging and also this GO :0042802 : identical protein binding and also this GO :0043274 : phospholipase binding, bridging and molecular function this GO :0031133 and regulation of axon diameter and biological process this GO :0033596 and TSC1-TSC2 complex and cellular component this GO :0033693 and neurofilament bundle assembly and biological process this GO :0040011 and locomotion and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043274 and phospholipase binding and molecular function this GO :0043434 and response to peptide hormone and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0045109 and intermediate filament organization and biological process this GO :0045110 and intermediate filament bundle assembly and biological process this GO :0048812 and neuron projection morphogenesis and biological process this GO :0050772 and positive regulation of axonogenesis and biological process this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0051258 and protein polymerization and biological process this GO :0051412 and response to corticosterone and biological process this GO :0060052 and neurofilament cytoskeleton organization and biological process, light polypeptide, protein binding, this GO :0000226 and microtubule cytoskeleton organization and biological process this GO :0005198 and structural molecule activity and molecular function this GO :0005200 and structural constituent of cytoskeleton and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005882 and intermediate filament and cellular component this GO :0005883 and neurofilament and cellular component this GO :0007268 and synaptic transmission and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008089 and anterograde axon car this GO transport and biological process this GO :0008090 and retrograde axon car this GO transport and biological process this GO :0008219 and cell death and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010033 and response to organic substance and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0014012 and peripheral nervous system axon regeneration and biological process this GO :0019896 and axon transport of mitochondrion and biological process this GO :0019904 and protein domain specific binding and molecular function this GO :0030424 and axon and cellular component this GO :0030426 and growth cone and cellular component this GO :0030674 and protein binding, this GO :0005198 : structural molecule activity, this GO :0005198 : structural molecule activity and also this GO :0005200 : structural constituent of cytoskeleton and also this GO :0005515 : protein binding and also this GO :0008022 : protein C-terminus binding and also this GO :0019904 : protein domain specific binding and also this GO :0030674 : protein binding, this GO :0005200 : structural constituent of cytoskeleton, this GO :0005515 : protein binding, this GO :0008022 : protein C-terminus binding, this GO :0019904 : protein domain specific binding, this GO :0030674 : protein binding, this GO :0042802 : identical protein binding, this GO :0043274 : phospholipase binding, neurofilament |
| Identity: |
7739 |
| Gene: |
NEFL |
More about : NEFL |
| Long gene name: |
neurofilament light |
| Synonyms gene name: |
light polypeptide , light polypeptide 68kDa neurofilament, neurofilament |
| Synonyms: |
NFL CMT1F CMT2E NF68 PPP1R110 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 110 |
| Locus: |
8p21, 2 |
| Discovery year: |
2001-06-22 |
| Entrez gene record: |
4747 |
| Pubmed identfication: |
17620486 3145240 |
| RefSeq identity: |
NM_006158 |
| Classification: |
Intermediate filaments Type IV Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000134284 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_259 |