| Also known as: |
IL12B / IL12 p40 |
| Other names: |
40 kD subunit, CLMF p40, CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12 subunit p40, IL12, Interleukin-12 subunit beta, NK cell stimulatory factor chain 2, NK cell stimulatory factor chain 2, NKSF2, cytotoxic lymphocyte maturation factor 2, cytotoxic lymphocyte maturation factor 40 kDa subunit, interleukin 12, interleukin 12B, interleukin 12B (natural killer cell stimulatory factor 2, interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, p40, p40), subunit p40, interleukin-12 subunit beta |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
IL12B |
| Gene name synonims: |
IL12 p40 |
| Other gene names: |
CLMF, CLMF p40, CLMF2, IL-12B, IL-12B, IL12B, IMD28, IMD29, NKSF, NKSF2, NKSF2, NKSF2, IL12B |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1, k |
| Clone: |
6, C8 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, N/A |
| Purification method: |
Affinity Purified |
| Form/Appearance: |
0, 150 mM sodium chloride, pH 7, 09% sodium azide, 2, PBS |
| Concentration: |
5 mg/ml |
| Storage and shipping: |
avoid repeated freeze thaw cycles, Store the antibody at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC/FACS), Neutralization, Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
6] (IgG1, Monoclonal [ C8, k) IL12B / IL12 p40 |
| Short name: |
6] (IgG1, Mouse Monoclonal [clone C8, k) IL12B / IL12 p40 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
cytotoxic lymphocyte maturation factor 2, p40) / IL12 p40 (Antibody to), sapiens interleukin 12B (natural killer cellular stimulatory factor 2, 6] (IgG1, Mouse monoclonal [clonality C8, k) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CLMF and CLMF2 and IL-12B and IMD28 and IMD29 and NKSF and NKSF2, Extracellular, IL12B and IDBG-55893 and ENSG00000113302 and 3593, IL12B and IDBG-646420 and ENSBTAG00000004741 and 281857, Il12b and IDBG-164545 and ENSMUSG00000004296 and 16160, cytotoxic lymphocyte maturation factor 2, p40), protein heterodimerization activity, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002230 and positive regulation of defense response to virus by host and biological process this GO :0002323 and natural killer cell activation involved in immune response and biological process this GO :0002827 and positive regulation of T-helper 1 type immune response and biological process this GO :0002860 and positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target and biological process this GO :0002862 and negative regulation of inflammatory response to antigenic stimulus and biological process this GO :0004896 and cytokine receptor activity and molecular function this GO :0005125 and cytokine activity and molecular function this GO :0005126 and cytokine receptor binding and molecular function this GO :0005143 and interleukin-12 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007050 and cell cycle arrest and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0008083 and growth factor activity and molecular function this GO :0010224 and response to UV-B and biological process this GO :0010535 and positive regulation of activation of JAK2 kinase activity and biological process this GO :0016020 and membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019233 and sensory perception of pain and biological process this GO :0019953 and sexual reproduction and biological process this GO :0030101 and natural killer cell activation and biological process this GO :0032693 and negative regulation of interleukin-10 production and biological process this GO :0032700 and negative regulation of interleukin-17 production and biological process this GO :0032725 and positive regulation of granulocyte macrophage colony-stimulating factor production and biological process this GO :0032729 and positive regulation of interferon-gamma production and biological process this GO :0032733 and positive regulation of interleukin-10 production and biological process this GO :0032735 and positive regulation of interleukin-12 production and biological process this GO :0032740 and positive regulation of interleukin-17 production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0032816 and positive regulation of natural killer cell activation and biological process this GO :0032819 and positive regulation of natural killer cell proliferation and biological process this GO :0032946 and positive regulation of mononuclear cell proliferation and biological process this GO :0034105 and positive regulation of tissue remodeling and biological process this GO :0034393 and positive regulation of smooth muscle cell apoptotic process and biological process this GO :0042035 and regulation of cytokine biosynthetic process and biological process this GO :0042088 and T-helper 1 type immune response and biological process this GO :0042093 and T-helper cell differentiation and biological process this GO :0042095 and interferon-gamma biosynthetic process and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042104 and positive regulation of activated T cell proliferation and biological process this GO :0042164 and interleukin-12 alpha subunit binding and molecular function this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0042510 and regulation of tyrosine phosphorylation of Stat1 protein and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042520 and positive regulation of tyrosine phosphorylation of Stat4 protein and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042832 and defense response to protozoan and biological process this GO :0043382 and positive regulation of memory T cell differentiation and biological process this GO :0043514 and interleukin-12 complex and cellular component this GO :0044130 and negative regulation of growth of symbiont in host and biological process this GO :0045078 and positive regulation of interferon-gamma biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045519 and interleukin-23 receptor binding and molecular function this GO :0045672 and positive regulation of osteoclast differentiation and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048662 and negative regulation of smooth muscle cell proliferation and biological process this GO :0050671 and positive regulation of lymphocyte proliferation and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0050829 and defense response to Gram-negative bacterium and biological process this GO :0051135 and positive regulation of NK T cell activation and biological process this GO :0051142 and positive regulation of NK T cell proliferation and biological process this GO :0051607 and defense response to virus and biological process this GO :0070743 and interleukin-23 complex and cellular component this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071346 and cellular response to interferon-gamma and biological process this GO :2000318 and positive regulation of T-helper 17 type immune response and biological process this GO :2000330 and positive regulation of T-helper 17 cell lineage commitment and biological process, this GO :0004896 : cytokine receptor activity, this GO :0004896 : cytokine receptor activity and also this GO :0005125 : cytokine activity and also this GO :0005126 : cytokine receptor binding and also this GO :0005143 : interleukin-12 receptor binding and also this GO :0005515 : protein binding and also this GO :0008083 : growth factor activity and also this GO :0042164 : interleukin-12 alpha subunit binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0045519 : interleukin-23 receptor binding and also this GO :0046982 : protein heterodimerization activity, this GO :0005125 : cytokine activity, this GO :0005126 : cytokine receptor binding, this GO :0005143 : interleukin-12 receptor binding, this GO :0005515 : protein binding, this GO :0008083 : growth factor activity, this GO :0042164 : interleukin-12 alpha subunit binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0045519 : interleukin-23 receptor binding, this GO :0046982 : protein heterodimerization activity, interleukin 12B (natural killer cell stimulatory factor 2 |
| Identity: |
5970 |
| Gene: |
IL12B |
More about : IL12B |
| Long gene name: |
interleukin 12B |
| Synonyms gene: |
NKSF2 |
| Synonyms gene name: |
cytotoxic lymphocyte maturation factor 2, interleukin 12B (natural killer cell stimulatory factor 2, p40) |
| Synonyms: |
CLMF IL-12B NKSF CLMF2 |
| Synonyms name: |
40 kD subunit interleukin-12 beta chain IL12, natural killer cell stimulatory factor-2 cytotoxic lymphocyte maturation factor 2, p40 interleukin 12, p40 natural killer cell stimulatory factor, subunit p40 |
| Locus: |
5q33, 3 |
| Discovery year: |
1991-08-08 |
| GenBank acession: |
M65290 |
| Entrez gene record: |
3593 |
| Pubmed identfication: |
1673147 |
| RefSeq identity: |
NM_002187 |
| Classification: |
Interleukins Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000130307 |
| Locus Specific Databases: |
IL12Bbase: Mutation registry for Interleukin-12 (IL-12) p40 deficiency LRG_71 |