| Also known as: |
SMO / Smoothened |
| Other names: |
Protein Gx, Smoothened homolog, frizzled class receptor, frizzled family member 11, frizzled family receptor, protein Gx, seven transmembrane helix receptor, seven transmembrane spanning receptor, smoothened, smoothened, smoothened, smoothened homolog, smoothened homolog |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
SMO |
| Other gene names: |
FZD11, Gx, SMO, SMO, SMOH, SMOH, SMO |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a, k |
| Clone: |
3D10 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Human SMO / Smoothened |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
pH 7, 4, PBS |
| Concentration: |
5 mg/ml |
| Storage and shipping: |
Aliquot to avoid repeated freezing and thawing, or lower, Store the antibody should be stored at -20 degrees Celsius |
| Tested applications:: |
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 3D10] (IgG2a, k) SMO / Smoothened |
| Short name: |
Mouse Monoclonal [clone 3D10] (IgG2a, k) SMO / Smoothened Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG2a |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
frizzled family receptor / Smoothened (Antibody to), sapiens smoothened, Mouse monoclonal [clonality 3D10] (IgG2a, k) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, FZD11 and Gx and SMOH, SMO and IDBG-40669 and ENSG00000128602 and 6608, SMO and IDBG-635317 and ENSBTAG00000013287 and 539308, Smo and IDBG-132261 and ENSMUSG00000001761 and 319757, Wnt-activated receptor activity, frizzled family receptor, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0001503 and ossification and biological process this GO :0001570 and vasculogenesis and biological process this GO :0001649 and osteoblast differentiation and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001708 and cell fate specification and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0001947 and heart looping and biological process this GO :0002052 and positive regulation of neuroblast proliferation and biological process this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0003140 and determination of left/right asymmetry in lateral mesoderm and biological process this GO :0003323 and type B pancreatic cell development and biological process this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005113 and patched binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005901 and caveola and cellular component this GO :0005929 and cilium and cellular component this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007224 and smoothened signaling pathway and biological process this GO :0007228 and positive regulation of hh target transcription factor activity and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007368 and determination of left/right symmetry and biological process this GO :0007371 and ventral midline determination and biological process this GO :0007389 and pattern specification process and biological process this GO :0007417 and central nervous system development and biological process this GO :0007494 and midgut development and biological process this GO :0008144 and drug binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008406 and this GO nad development and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0009953 and dorsal/ventral pattern formation and biological process this GO :0010002 and cardioblast differentiation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0017147 and Wnt-protein binding and molecular function this GO :0021508 and floor plate formation and biological process this GO :0021561 and facial nerve development and biological process this GO :0021696 and cerebellar cortex morphogenesis and biological process this GO :0021794 and thalamus development and biological process this GO :0021904 and dorsal/ventral neural tube patterning and biological process this GO :0021910 and smoothened signaling pathway involved in ventral spinal cord patterning and biological process this GO :0021938 and smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation and biological process this GO :0021953 and central nervous system neuron differentiation and biological process this GO :0021984 and adenohypophysis development and biological process this GO :0030165 and PDZ domain binding and molecular function this GO :0030857 and negative regulation of epithelial cell differentiation and biological process this GO :0031017 and exocrine pancreas development and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0031076 and embryonic camera-type eye development and biological process this GO :0031102 and neuron projection regeneration and biological process this GO :0032474 and otolith morphogenesis and biological process this GO :0034504 and protein localization to nucleus and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0042307 and positive regulation of protein import into nucleus and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042693 and muscle cell fate commitment and biological process this GO :0042813 and Wnt-activated receptor activity and molecular function this GO :0043025 and neuronal cell body and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043392 and negative regulation of DNA binding and biological process this GO :0045880 and positive regulation of smoothened signaling pathway and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048468 and cell development and biological process this GO :0048557 and embryonic digestive tract morphogenesis and biological process this GO :0048565 and digestive tract development and biological process this GO :0048568 and embryonic organ development and biological process this GO :0048589 and developmental growth and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048702 and embryonic neurocranium morphogenesis and biological process this GO :0048703 and embryonic viscerocranium morphogenesis and biological process this GO :0048741 and skeletal muscle fiber development and biological process this GO :0048752 and semicircular canal morphogenesis and biological process this GO :0048846 and axon extension involved in axon guidance and biological process this GO :0048853 and forebrain morphogenesis and biological process this GO :0050679 and positive regulation of epithelial cell proliferation and biological process this GO :0050821 and protein stabilization and biological process this GO :0051451 and myoblast migration and biological process this GO :0051799 and negative regulation of hair follicle development and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060170 and ciliary membrane and cellular component this GO :0060248 and detection of cell density by contact stimulus involved in contact inhibition and biological process this GO :0060413 and atrial septum morphogenesis and biological process this GO :0060644 and mammary gland epithelial cell differentiation and biological process this GO :0060684 and epithelial-mesenchymal cell signaling and biological process this GO :0060830 and ciliary receptor clustering involved in smoothened signaling pathway and biological process this GO :0061053 and somite development and biological process this GO :0061113 and pancreas morphogenesis and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071397 and cellular response to cholesterol and biological process this GO :0072001 and renal system development and biological process this GO :0072285 and mesenchymal to epithelial transition involved in metanephric renal vesicle formation and biological process this GO :0072372 and primary cilium and cellular component this GO :0090190 and positive regulation of branching involved in ureteric bud morphogenesis and biological process this GO :2000036 and regulation of stem cell maintenance and biological process this GO :2000826 and regulation of heart morphogenesis and biological process, this GO :0004888 : transmembrane signaling receptor activity, this GO :0004888 : transmembrane signaling receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0005113 : patched binding and also this GO :0005515 : protein binding and also this GO :0008144 : drug binding and also this GO :0017147 : Wnt-protein binding and also this GO :0030165 : PDZ domain binding and also this GO :0042813 : Wnt-activated receptor activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0005113 : patched binding, this GO :0005515 : protein binding, this GO :0008144 : drug binding, this GO :0017147 : Wnt-protein binding, this GO :0030165 : PDZ domain binding, this GO :0042813 : Wnt-activated receptor activity, smoothened |
| Identity: |
11119 |
| Gene: |
SMO |
More about : SMO |
| Long gene name: |
frizzled class receptor , smoothened |
| Synonyms gene: |
SMOH |
| Synonyms gene name: |
frizzled family receptor , seven transmembrane spanning receptor smoothened, smoothened (Drosophila) homolog smoothened homolog (Drosophila) smoothened |
| Synonyms: |
FZD11 |
| Synonyms name: |
frizzled family member 11 |
| Locus: |
7q32, 1 |
| Discovery year: |
1996-12-18 |
| GenBank acession: |
U84401 |
| Entrez gene record: |
6608 |
| Pubmed identfication: |
9628830 |
| RefSeq identity: |
NM_005631 |
| Classification: |
Class F frizzled , G protein-coupled receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000158421 |