| Also known as: |
PRNP / PrP / Prion |
| Other names: |
ASCR, CD230 antigen, CD_antigen: CD230, Major prion protein, PrP27-30, PrP33-35C, alternative prion protein, major prion protein, prion protein, prion-related protein, major prion protein preproprotein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
PRNP |
| Other gene names: |
ALTPRP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PRIP, PRNP, PRP, PrP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, PRNP |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
EM-20 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Diglycosylated form of PrP has ~40 kD, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prion protein, This particular antibody might cross react with speacies outside of the listed ones, and nonglycosylated form ~19-21 kD, monoglycosylated form ~30 kD, The mouse monoclonal antibody EM-20 recognizes human prion protein (PrP) |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
15 mM sodium azide, pH 7, 4, PBS |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ EM-20] (IgG2a) PRNP / PrP / Prion |
| Short name: |
Mouse Monoclonal [clone EM-20] (IgG2a) PRNP / PrP / Prion Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG2a |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens prion protein / PrP / Prion (Antibody to), Mouse monoclonal [clonality EM-20] (IgG2a) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AltPrP and ASCR and CD230 and CJD and GSS and KURU and p27-30 and PRIP and PrP and PrP27-30 and PrP33-35C and PrPc, PRNP and IDBG-49833 and ENSG00000171867 and 5621, PRNP and IDBG-639760 and ENSBTAG00000027937 and 281427, Prnp and IDBG-260830 and ENSMUSG00000079037 and 19122, chaperone binding, nuclei, this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0005507 and copper ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006878 and cellular copper ion homeostasis and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007411 and axon guidance and biological process this GO :0007611 and learning or memory and biological process this GO :0008017 and microtubule binding and molecular function this GO :0008152 and metabolic process and biological process this GO :0015631 and tubulin binding and molecular function this GO :0016020 and membrane and cellular component this GO :0019898 and extrinsic component of membrane and cellular component this GO :0031225 and anchored component of membrane and cellular component this GO :0032689 and negative regulation of interferon-gamma production and biological process this GO :0032700 and negative regulation of interleukin-17 production and biological process this GO :0032703 and negative regulation of interleukin-2 production and biological process this GO :0032880 and regulation of protein localization and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043008 and ATP-dependent protein binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0045121 and membrane raft and cellular component this GO :0046007 and negative regulation of activated T cell proliferation and biological process this GO :0046686 and response to cadmium ion and biological process this GO :0046688 and response to copper ion and biological process this GO :0050860 and negative regulation of T cell receptor signaling pathway and biological process this GO :0051087 and chaperone binding and molecular function this GO :0051260 and protein homooli this GO merization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070885 and negative regulation of calcineurin-NFAT signaling cascade and biological process this GO :1901379 and regulation of potassium ion transmembrane transport and biological process, this GO :0005507 : copper ion binding, this GO :0005507 : copper ion binding and also this GO :0005515 : protein binding and also this GO :0008017 : microtubule binding and also this GO :0015631 : tubulin binding and also this GO :0042802 : identical protein binding and also this GO :0043008 : ATP-dependent protein binding and also this GO :0051087 : chaperone binding, this GO :0005515 : protein binding, this GO :0008017 : microtubule binding, this GO :0015631 : tubulin binding, this GO :0042802 : identical protein binding, this GO :0043008 : ATP-dependent protein binding, this GO :0051087 : chaperone binding, prion protein |
| Identity: |
9449 |
| Gene: |
PRNP |
More about : PRNP |
| Long gene name: |
prion protein |
| Synonyms gene: |
PRIP GSS CJD |
| Synonyms gene name: |
prion protein (p27-30) |
| Synonyms: |
CD230 PRP AltPrP |
| Synonyms name: |
Creutzfeldt-Jakob disease Gerstmann-Strausler-Scheinker syndrome fatal familial insomnia p27-30 |
| Locus: |
20p13 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M13899 |
| Entrez gene record: |
5621 |
| RefSeq identity: |
NM_000311 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000031786 |
| Locus Specific Databases: |
Prion Protein/CJD database |