| Also known as: |
TOP2A / Topoisomerase II Alpha |
| Other names: |
170 kD, DNA gyrase, DNA topoisomerase (ATP-hydrolyzing), DNA topoisomerase 2-alpha, DNA topoisomerase 2-alpha, DNA topoisomerase II, DNA topoisomerase II, DNA topoisomerase II, alpha isozyme, alpha isozyme, topoisomerase (DNA) II alpha 170kDa, DNA topoisomerase 2-alpha |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TOP2A |
| Other gene names: |
TOP2, TOP2, TOP2A, TP2A, TOP2A |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1, k |
| Clone: |
100 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, N/A |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
pH 7, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
We strongly recommend to avoid freeze/thaw cycles in order to keep the activity of the antibody maximally unchanged, the antibody should be kept at -20 degrees Celsius, For optimal long term storage |
| Tested applications:: |
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Description: |
- or alpha protein sometimes glycoprotein present in blood, The Mouse Monoclonal [clone 1E2] (IgG1, k) TOP2A / Topoisomerase II Alpha Antibody is a &alpha |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 1E2] (IgG1, k) TOP2A / Topoisomerase II Alpha |
| Short name: |
Mouse Monoclonal [clone 1E2] (IgG1, k) TOP2A / Topoisomerase II Alpha Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens topoisomerase (Desoxyribonucleic acid) II alpha 170kDa / Topoisomerase II a (Antibody to), Mouse monoclonal [clonality 1E2] (IgG1, k) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA binding, TOP2 and TP2A, TOP2A and IDBG-47552 and ENSG00000131747 and 7153, TOP2A and IDBG-639659 and ENSBTAG00000019262 and 787696, Top2a and IDBG-210864 and ENSMUSG00000020914 and 21973, bending, bending and also this GO :0019899 : enzyme binding and also this GO :0042803 : protein homodimerization activity and also this GO :0042826 : histone deacetylase binding and also this GO :0043130 : ubiquitin binding and also this GO :0044822 : poly(A) RNA binding and also this GO :0046982 : protein heterodimerization activity, bending and molecular function this GO :0009330 and DNA topoisomerase complex (ATP-hydrolyzing) and cellular component this GO :0019035 and viral integration complex and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0030261 and chromosome condensation and biological process this GO :0030263 and apoptotic chromosome condensation and biological process this GO :0040016 and embryonic cleavage and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042826 and histone deacetylase binding and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043130 and ubiquitin binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0044774 and mitotic DNA integrity checkpoint and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045070 and positive regulation of viral genome replication and biological process this GO :0045870 and positive regulation of retroviral genome replication and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048015 and phosphatidylinositol-mediated signaling and biological process, nuclei, this GO :0000228 and nuclear chromosome and cellular component this GO :0000278 and mitotic cell cycle and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0000712 and resolution of meiotic recombination intermediates and biological process this GO :0000793 and condensed chromosome and cellular component this GO :0000819 and sister chromatid segregation and biological process this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003918 and DNA topoisomerase (ATP-hydrolyzing) activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005814 and centriole and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006260 and DNA replication and biological process this GO :0006265 and DNA topological change and biological process this GO :0006266 and DNA ligation and biological process this GO :0006268 and DNA unwinding involved in DNA replication and biological process this GO :0006281 and DNA repair and biological process this GO :0006312 and mitotic recombination and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007059 and chromosome segregation and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0008144 and drug binding and molecular function this GO :0008301 and DNA binding, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003918 : DNA topoisomerase (ATP-hydrolyzing) activity and also this GO :0005080 : protein kinase C binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008022 : protein C-terminus binding and also this GO :0008094 : DNA-dependent ATPase activity and also this GO :0008144 : drug binding and also this GO :0008301 : DNA binding, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003918 : DNA topoisomerase (ATP-hydrolyzing) activity, this GO :0005080 : protein kinase C binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008022 : protein C-terminus binding, this GO :0008094 : DNA-dependent ATPase activity, this GO :0008144 : drug binding, this GO :0008301 : DNA binding, this GO :0019899 : enzyme binding, this GO :0042803 : protein homodimerization activity, this GO :0042826 : histone deacetylase binding, this GO :0043130 : ubiquitin binding, this GO :0044822 : poly(A) RNA binding, this GO :0046982 : protein heterodimerization activity, topoisomerase (DNA) II alpha 170kDa |
| Identity: |
11989 |
| Gene: |
TOP2A |
More about : TOP2A |
| Long gene name: |
topoisomerase (DNA) II alpha |
| Synonyms gene: |
TOP2 |
| Synonyms gene name: |
topoisomerase (DNA) II alpha 170kDa |
| Locus: |
17q21, 2 |
| Discovery year: |
1989-03-23 |
| Entrez gene record: |
7153 |
| Classification: |
Topoisomerases |
| Havana BLAST/BLAT: |
OTTHUMG00000155008 |