| Also known as: |
ESA / EPCAM |
| Other names: |
Adenocarcinoma-associated antigen, CD_antigen: CD326, Cell surface glycoprotein Trop-1, EGP, EGP314, Epithelial cell adhesion molecule, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, Tumor-associated calcium signal transducer 1, adenocarcinoma-associated antigen, cell surface glycoprotein Trop-1, chromosome 4, epithelial cell adhesion molecule, epithelial cell adhesion molecule, epithelial glycoprotein 314, hEGP314, human epithelial glycoprotein-2, major gastrointestinal tumor-associated protein GA733-2, membrane component, surface marker (35kD glycoprotein), tumor-associated calcium signal transducer 1, epithelial cell adhesion molecule |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
ESA |
| Gene name synonims: |
EPCAM |
| Other gene names: |
DIAR5, EGP, EGP-2, EGP314, EGP314, EGP40, EPCAM, ESA, Ep-CAM, GA733-2, HNPCC8, KS1/4, KSA, M1S2, M4S1, M4S1, MIC18, MIC18, MK-1, TACSTD1, TACSTD1, TROP1, TROP1, hEGP314, EPCAM |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MOC-31 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
MOC-31 is not reactive with normal and malignant mesothelia and therefore is especially useful for the detection of carcinoma cells in ascites or pleural effusions (4), MOC-31 reacts with most epithelia, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The membrane-associated proteins detected by MOC-31 appear to have an apparent molecular weight of 35-40 kD, This particular antibody might cross react with speacies outside of the listed ones, all lung carcinomas, and, in lung cancer, This antibody is reactive with lung cancer associated antigens and has been studied and categorized in different clusters of reactivity patterns during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987 |
| Purification method: |
Tissue culture supernatant |
| Form/Appearance: |
<, 1% sodium azide, Tissue culture supernatant (8% FBS) |
| Storage and shipping: |
Store undiluted, Temperature variations in the range between +1C to +7C are tolerable, +Keep the antibody refrigerated at +4 degrees Celsius |
| Tested applications:: |
IHC - Frozen), Western Blot (WB), Immunohistochemistry (IHC - Paraffin |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ MOC-31] (IgG1) ESA / EPCAM |
| Short name: |
Mouse Monoclonal [clone MOC-31] (IgG1) ESA / EPCAM Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens ESA / epithelial cellular adhesion molecule (Antibody to), Mouse monoclonal [clonality MOC-31] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, DIAR5 and EGP-2 and EGP314 and EGP40 and ESA and HNPCC8 and KS1/4 and KSA and M4S1 and MIC18 and MK-1 and TACSTD1 and TROP1, EPCAM and IDBG-50831 and ENSG00000119888 and 4072, EPCAM and IDBG-633617 and ENSBTAG00000006474 and 514039, Epcam and IDBG-201437 and ENSMUSG00000045394 and 17075, protein complex binding, this GO :0001657 and ureteric bud development and biological process this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005923 and tight junction and cellular component this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0016328 and lateral plasma membrane and cellular component this GO :0023019 and signal transduction involved in regulation of gene expression and biological process this GO :0032403 and protein complex binding and molecular function this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048863 and stem cell differentiation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :2000048 and negative regulation of cell-cell adhesion mediated by cadherin and biological process this GO :2000648 and positive regulation of stem cell proliferation and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0032403 : protein complex binding, this GO :0032403 : protein complex binding, epithelial cell adhesion molecule |
| Identity: |
11529 |
| Gene: |
EPCAM |
More about : EPCAM |
| Long gene name: |
epithelial cell adhesion molecule |
| Synonyms gene: |
M4S1 MIC18 TACSTD1 |
| Synonyms gene name: |
antigen identified by monoclonal antibody AUA1 tumor-associated calcium signal transducer 1 |
| Synonyms: |
Ly74 TROP1 GA733-2 EGP34 EGP40 EGP-2 KSA CD326 Ep-CAM HEA125 KS1/4 MK-1 MH99 MOC31 323/A3 17-1A TACST-1 CO-17A ESA |
| Locus: |
2p21 |
| Discovery year: |
1995-10-02 |
| GenBank acession: |
M33011 |
| Entrez gene record: |
4072 |
| Pubmed identfication: |
8382772 11306819 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000128853 |
| Locus Specific Databases: |
Colon cancer gene variant databases LRG_215 |