| Also known as: |
SOCS3 |
| Other names: |
CIS-3, Cytokine-inducible SH2 protein 3, SSI-3, STAT-induced STAT inhibitor 3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3, cytokine-inducible SH2 protein 3, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
SOCS3 |
| Other gene names: |
ATOD4, CIS-3, CIS3, CIS3, Cish3, SOCS-3, SOCS-3, SOCS3, SSI-3, SSI-3, SSI3, SSI3, SOCS3 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
SO1 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Colitis, IL-10, SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumor studies, SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The expression of SOCS3 is inducible by numerous factors, This particular antibody might cross react with speacies outside of the listed ones, Toll-like receptor (TLR) agonists and IFN gamma, a 30kD member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways, and Crohn's Disease, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, including IL-6, making this protein the focus of research into inflammatory diseases, such as Arthritis, thereby preventing the IL-6 activation of STAT3, Recognizes suppressor of cytokine signaling 3 (SOCS3) |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
0, Sourced in TCS, pH 7, 09% sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ SO1] (IgG2b) SOCS3 |
| Short name: |
Mouse Monoclonal [clone SO1] (IgG2b) SOCS3 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG2b |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens suppressor on cytokine signaling 3 (Antibody to), Mouse monoclonal [clonality SO1] (IgG2b) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ATOD4 and CIS3 and Cish3 and SOCS-3 and SSI-3 and SSI3, Cytoplasm, SOCS3 and IDBG-647946 and ENSBTAG00000008441 and 282081, SOCS3 and IDBG-70676 and ENSG00000184557 and 9021, Socs3 and IDBG-214604 and ENSMUSG00000053113 and 12702, protein binding, this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045595 and regulation of cell differentiation and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0060670 and branching involved in labyrinthine layer morphogenesis and biological process this GO :0060674 and placenta blood vessel development and biological process this GO :0060707 and trophoblast giant cell differentiation and biological process this GO :0060708 and spongiotrophoblast differentiation and biological process, this GO :0004860 : protein kinase inhibitor activity, this GO :0004860 : protein kinase inhibitor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, suppressor of cytokine signaling 3 |
| Identity: |
19391 |
| Gene: |
SOCS3 |
More about : SOCS3 |
| Long gene name: |
suppressor of cytokine signaling 3 |
| Synonyms: |
SSI-3 CIS3 SOCS-3 Cish3 |
| Locus: |
17q25, 3 |
| Discovery year: |
2002-11-13 |
| GenBank acession: |
AB004904 |
| Entrez gene record: |
9021 |
| Pubmed identfication: |
9266833 9344848 |
| Classification: |
Suppressors of cytokine signaling SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000177513 |
| Locus Specific Databases: |
LRG_619 |