| Also known as: |
CD95 / FAS |
| Other names: |
APO-1 cell surface antigen, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, CD95 antigen, CD_antigen: CD95, Delta Fas/APO-1/CD95, FAS 827dupA, FAS receptor variant 9, FASLG receptor, FASLG receptor, Fas (TNF receptor superfamily, Fas AMA, Fas cell surface death receptor, TNF receptor superfamily member 6, Tumor necrosis factor receptor superfamily member 6, apoptosis antigen 1, apoptosis-mediating surface antigen FAS, member 6, member 6), tumor necrosis factor receptor superfamily, tumor necrosis factor receptor superfamily member 6, tumor necrosis factor receptor superfamily member 6 isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD95 |
| Gene name synonims: |
FAS |
| Other gene names: |
ALPS1A, APO-1, APT1, APT1, CD95, FAS, FAS1, FAS1, FASTM, TNFRSF6, TNFRSF6, FAS |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
LT95 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
It seems that the antibody LT95 does not induce Fas mediated apoptosis, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, a 46 kD single chain type I glycoprotein of the tumor necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule, expressed on a variety of normal and neoplastic cells, Reacts with CD95 (Fas/APO-1) |
| Purification method: |
Ion exchange Chromatography |
| Form/Appearance: |
15 mM sodium azide, approx, pH 7, 20 mM Tris/HCl, 4 |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ LT95] (IgG1) CD95 / FAS |
| Short name: |
Mouse Monoclonal [clone LT95] (IgG1) CD95 / FAS Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
member 6) (Antibody to), sapiens CD95 / Fas (TNF receptor superfamily, Mouse monoclonal [clonality LT95] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ALPS1A and APO-1 and APT1 and CD95 and FAS1 and FASTM and TNFRSF6, FAS and IDBG-637356 and ENSBTAG00000010785 and 282488, FAS and IDBG-81669 and ENSG00000026103 and 355, Fas and IDBG-159577 and ENSMUSG00000024778 and 14102, identical protein binding, member 6), nuclei, this GO :0002377 and immunoglobulin production and biological process this GO :0003014 and renal system process and biological process this GO :0004871 and signal transducer activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006924 and activation-induced cell death of T cells and biological process this GO :0006925 and inflammatory cell apoptotic process and biological process this GO :0006927 and transformed cell apoptotic process and biological process this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007623 and circadian rhythm and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0009636 and response to toxic substance and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010467 and gene expression and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0019724 and B cell mediated immunity and biological process this GO :0019900 and kinase binding and molecular function this GO :0031264 and death-inducing signaling complex and cellular component this GO :0031265 and CD95 death-inducing signaling complex and cellular component this GO :0032464 and positive regulation of protein homooli this GO merization and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043029 and T cell homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045060 and negative thymic T cell selection and biological process this GO :0045121 and membrane raft and cellular component this GO :0045619 and regulation of lymphocyte differentiation and biological process this GO :0045637 and regulation of myeloid cell differentiation and biological process this GO :0048536 and spleen development and biological process this GO :0050869 and negative regulation of B cell activation and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071285 and cellular response to lithium ion and biological process this GO :0071455 and cellular response to hyperoxia and biological process this GO :0097049 and motor neuron apoptotic process and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097527 and necroptotic signaling pathway and biological process this GO :2001239 and regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001241 and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, this GO :0004871 : signal transducer activity, this GO :0004871 : signal transducer activity and also this GO :0004872 : receptor activity and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005515 : protein binding and also this GO :0019900 : kinase binding and also this GO :0042802 : identical protein binding, this GO :0004872 : receptor activity, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005515 : protein binding, this GO :0019900 : kinase binding, this GO :0042802 : identical protein binding, Fas (TNF receptor superfamily |
| Identity: |
11920 |
| Gene: |
FAS |
More about : FAS |
| Long gene name: |
Fas cell surface death receptor |
| Synonyms gene: |
FAS1 APT1 TNFRSF6 |
| Synonyms gene name: |
member 6 Fas (TNF receptor superfamily, member 6) , tumor necrosis factor receptor superfamily |
| Synonyms: |
CD95 APO-1 |
| Synonyms name: |
TNF receptor superfamily member 6 |
| Locus: |
10q23, 31 |
| Discovery year: |
1992-06-25 |
| GenBank acession: |
M67454 |
| Entrez gene record: |
355 |
| Pubmed identfication: |
1385299 1385309 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily Death inducing signaling complex |
| Havana BLAST/BLAT: |
OTTHUMG00000018701 |
| Locus Specific Databases: |
Autoimmune Lymphoproliferative Syndrome Database (ALPSbase): Database of mutations causing human ALPS LOVD at NCBI LRG_134 |