| Also known as: |
APOLIPOPROTEIN E |
| Other names: |
Apolipoprotein E, N/A, apo-E, apolipoprotein E, apolipoprotein E, apolipoprotein E3, apolipoprotein E |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
AD2, APOE, Apo-E, LDLCQ5, LPG, APOE |
| Gene name synonims: |
AD2, APOE, Apo-E, LDLCQ5, LPG, APOE |
| Other gene names: |
AD2, APOE, Apo-E, LDLCQ5, LPG, APOE |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
WUE-4 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, Apo-E is the principle apolipoprotein in the central nervous system, ApoE2, ApoE2 has been shown to bind LPL receptors with low affinity, ApoE4 is a known high risk factor for Alzheimer's disease, Clone WUE-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB, E3 and E4, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Three isoforms of Apo-E have been identified, a major component of very low-density lipoproteins (VLDLs), and considered the normal/natural Apo-E genotype, and have been linked with various disorders, and in particular late onset Alzheimer disease 2 (AD2), and is secreted by most organs into the plasma, and the apoB, and thereby an increased risk in cardiovascular disorders, internalization and catabolism of triglyceride-rich lipoprotein constituents, playing a vital role in the binding, resulting in increased plasma cholesterol and triglyceride levels, whilst ApoE3 is the most common isoform, APOLIPOPROTEIN E This item specifically recognises an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), E (LDL) receptor, E cell receptor |
| Form/Appearance: |
Low Endotoxin (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, only, the antibody should be stored undiluted, Store the antibody should be stored at -20 degrees Celsius |
| Tested applications:: |
ELISA (EIA), Western Blot (WB), Functional Assay (FA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
APOLIPOPROTEIN E: Endotoxin |
| Short name: |
MOUSE Anti-HUMAN APOLIPOPROTEIN E:Low Endotoxin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens APOLIPOPROTEIN E:Low Endotoxin (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |