| Also known as: |
CD45 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD45 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
UM16-6 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Chicken |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies have indicated that dephosphorylation by CD45 is required for the activation of the src-family kinases p56<, The overall domain structure between mammalian and chicken CD45 appears to be conserved, This particular antibody might cross react with speacies outside of the listed ones, Variation in the expression of a particular CD45 isoform is regulated during the haematopoietic development of the different cell lineages, _x000D__x000D_CD45 is essential for antigen-induced signal transduction through the antigen receptor and as with other PTPase family members, _x000D__x000D_Investigations into the properties of CD45 in chicken models are limited, a heavily-glycosylated transmembrane protein tyrosine phosphatase (PTPase) expressed by all nucleated cells of haematopoietic origin, acts in balance with protein tyrosine kinases, and p59<, but the sequence homology between the extracellular regions is very low, but there is evidence of the existence of an additional cysteine residue near the transmembrane region, causing the dephosphorylation of negative regulatory tyrosine sites, /sup>, /sup>, CD45 Clone UM16-6 recognizes chicken CD45 (leucocyte common antigen), fyn<, lck<, sup>, sup> |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Frozen (IHC), Immunoprecipitation (IP) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD45 |
| Short name: |
MOUSE Anti-CHICKEN CD45 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MOUSE antibody to-CHICKEN CD45 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9666 |
| Gene: |
PTPRC |
More about : PTPRC |
| Long gene name: |
protein tyrosine phosphatase, receptor type C |
| Synonyms gene: |
CD45 |
| Synonyms: |
LCA T200 GP180 |
| Locus: |
1q31, 1 , 3-q32 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
Y00062 |
| Entrez gene record: |
5788 |
| Pubmed identfication: |
2169617 |
| RefSeq identity: |
NM_002838 |
| Classification: |
Fibronectin type III domain containing CD molecules Protein tyrosine phosphatases, receptor type |
| Havana BLAST/BLAT: |
OTTHUMG00000035702 |
| Locus Specific Databases: |
PTPRCbase: Mutation registry for CD45 deficiency LRG_95 |