| Also known as: |
JAGGED2 |
| Other names: |
N/A, Protein jagged-2, jagged 2, protein jagged-2, protein jagged-2 isoform a |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
JAGGED2 |
| Other gene names: |
HJ2, JAG2, Jagged2, SER2, hJ2, JAG2 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
HMJ2-1 |
| Host organism: |
Hamster |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
DLL3 and DLL4, Delta like-1 (DLL1), Jagged1 (CD339), Jagged2, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Jagged2 is expressed by stromal and thymic lymphoid cells, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_Studies have shown that the anti-tumour cytolytic activity of natural killer (NK) cells can be enhanced by Jagged2 stimulation, _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and both tumour progression and suppression, and by splenic macrophages and dendritic cells (DC), and plays a vital role during limb, and that the vital role which DC Jagged2 expression plays in DC-mediated NK cell activation, and thymic development, as well as being implicated in the maintenance and function of neuronal cells in both the central (CNS) and enteric (gastrointestinal) nervous system, cardiac and endocrine development, craniofacial, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, may occur through the interaction be, on physically adjacent signal receiving cells, one of the five major ligands of the Notch signalling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell haematopoiesis, thymic T-cell development, tooth, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, JAGGED2 This item specifically recognises Jagged2 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Frozen (IHC), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
JAGGED2 |
| Short name: |
HAMSTER ANTI MOUSE JAGGED2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAMSTER antibody to MOUSE JAGGED2 (Antibody to) |
| Alternative technique: |
antibodies |