| Also known as: |
CD253 |
| Other names: |
TNF-related apoptosis inducing ligand, TNF-related apoptosis-inducing ligand, TNF-related apoptosis-inducing ligand, TRAIL/APO2L, Tumor necrosis factor ligand superfamily member 10, member 10, tumor necrosis factor (ligand) superfamily, tumor necrosis factor ligand superfamily member 10, tumor necrosis factor ligand superfamily member 10 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD253 |
| Other gene names: |
A330042I21Rik, AI448571, APO-2L, Ly81, Protein TRAIL, TL2, Tnfsf10, Trail, Trail, Tnfsf10 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
N2B2 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD253 might also be bound by the decoy receptor DcR1 which cannot induce apoptosis, However, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, When bound to the death receptors DR4 and DR5 caspase-8-dependent apoptosis is induced, _x000D__x000D_Clone N2B2 has been reported to block NK cell cytotoxicity <, a member of the tumour necrosis factor ligand superfamily, also known as TNF-related apoptosis-inducing ligand or TRAIL, and DcR2 which activates NF-kappa-B, /i>, CD253 This item recognises mouse CD253, i>, in vitro< |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
IgG concentration 500ug/1000ul |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD253 |
| Short name: |
RAT ANTI MOUSE CD253 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD253 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11925 |
| Gene: |
TNFSF10 |
More about : TNFSF10 |
| Long gene name: |
tumor necrosis factor superfamily member 10 |
| Synonyms gene name: |
member 10 , tumor necrosis factor (ligand) superfamily |
| Synonyms: |
TRAIL Apo-2L TL2 CD253 |
| Locus: |
3q26 |
| Discovery year: |
1998-12-04 |
| GenBank acession: |
U37518 |
| Pubmed identfication: |
8777713 8663110 |
| Classification: |
Tumor necrosis factor superfamily CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000156917 |