| Also known as: |
DECTIN-1 |
| Other names: |
Beta-glucan receptor, C-type (calcium dependent, C-type lectin domain family 7, C-type lectin domain family 7 member A, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, C-type lectin superfamily member 12, DC-associated C-type lectin 1, Dendritic cell-associated C-type lectin 1, beta-glucan receptor, carbohydrate-recognition domain) lectin, dectin-1, dendritic cell-associated C-type lectin 1, dendritic cell-associated C-type lectin-1, lectin-like receptor 1, member A, superfamily member 12, C-type lectin domain family 7 member A isoform b |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
BGR, BGR, CANDF4, CLEC7A, CLECSF12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, DECTIN1, Dectin-1, CLEC7A |
| Gene name synonims: |
BGR, BGR, CANDF4, CLEC7A, CLECSF12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, DECTIN1, Dectin-1, CLEC7A |
| Other gene names: |
BGR, BGR, CANDF4, CLEC7A, CLECSF12, CLECSF12, DC-associated C-type lectin 1, DECTIN1, DECTIN1, Dectin-1, CLEC7A |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
GE2 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
?GR-A and ?GR-B differs by the presence and absence, Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, Clone GE2 could be used to inhibit receptor function, Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response, It is a major pathogen pattern-recognition receptor that binds beta-glucans, It is highly expressed on peripheral blood leukocytes and dendritic cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This item (clone GE2) recognises both of these isoforms, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Human Dectin-1 has two major (?GR-A and ?GR-B) and several minor isoforms, a C-type lectin domain family member, also known as beta-glucan receptor (?GR), as well as tumor formation, fungi and some bacteria, glucose polymers that form cell-wall components or exopolymers of yeasts, of a stalk region, respectively, viral and protozoan infections, yeast, DECTIN-1 This item recognises human Dectin-1 |
| Form/Appearance: |
Low Endotoxin (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, only, the antibody should be stored undiluted, Store the antibody should be stored at -20 degrees Celsius |
| Tested applications:: |
Functional Assay (FA), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
DECTIN-1: Endotoxin |
| Short name: |
MOUSE Anti-HUMAN DECTIN-1:Low Endotoxin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens DECTIN-1:Low Endotoxin (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
14558 |
| Gene: |
CLEC7A |
More about : CLEC7A |
| Long gene name: |
C-type lectin domain family 7 member A |
| Synonyms gene: |
CLECSF12 |
| Synonyms gene name: |
C-type (calcium dependent, carbohydrate-recognition domain) lectin, member A , superfamily member 12 C-type lectin domain family 7 |
| Synonyms: |
dectin-1 hDectin-1 CD369 SCARE2 |
| Locus: |
12p13, 2 |
| Discovery year: |
2001-02-01 |
| GenBank acession: |
AY009090 |
| Entrez gene record: |
64581 |
| RefSeq identity: |
NM_197954 |
| Classification: |
CD molecules Scavenger receptors C-type lectin domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000133597 |
| Locus Specific Databases: |
LRG_179 |