| Also known as: |
CD137 |
| Other names: |
4-1BB ligand receptor, 4-1BB ligand receptor, CD137 antigen, T-cell antigen 4-1BB, T-cell antigen 4-1BB, Tumor necrosis factor receptor superfamily member 9, member 9, secreted CD137 antigen, tumor necrosis factor receptor superfamily, tumor necrosis factor receptor superfamily member 9, tumor necrosis factor receptor superfamily member 9 isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD137 |
| Other gene names: |
4-1BB, A930040I11Rik, AA408498, AI325004, CDw137, Cd137, Cd137, ILA, Ila, Ly63, Ly63, Tnfrsf9, Tnfrsf9 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
17B5 |
| Host organism: |
Hamster |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Antibody cross-linking of CD137 on NK cells stimulates the secretion of IFN-gamma, CD137 is a potent costimulatory receptor for the growth and functional maturation of activated T-cells in the presence of T-cell receptor signal, CD137-mediated activation is distinct from and independent of CD28, CD25 expression and responsiveness to IL-2 and is associated with tumour activity, It is found on activated T-cells, NK cells, Signalling through CD137 triggers T-cell expansion, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone 17B5 may be used to block CD137-mediated T-cell proliferation, a member of the tumour necrosis factor superfamily, also known as 4-1BB ligand receptor, but not cytotoxicity, cellular proliferation, cytokine production and prevention of activation-induced death of effector T-cells, monocytes and dendritic cells, CD137 This item recognises mouse CD137 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD137 |
| Short name: |
HAMSTER ANTI MOUSE CD137 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAMSTER antibody to MOUSE CD137 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11924 |
| Gene: |
TNFRSF9 |
More about : TNFRSF9 |
| Long gene name: |
TNF receptor superfamily member 9 |
| Synonyms gene: |
ILA |
| Synonyms gene name: |
member 9 , tumor necrosis factor receptor superfamily |
| Synonyms: |
CD137 4-1BB |
| Locus: |
1p36, 23 |
| Discovery year: |
1996-06-12 |
| GenBank acession: |
L12964 |
| Entrez gene record: |
3604 |
| Pubmed identfication: |
8262389 8639902 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000001223 |