| Also known as: |
VON WILLEBRAND FACTOR |
| Other names: |
coagulation factor VIII VWF, von Willebrand antigen II, von Willebrand factor, von Willebrand factor, von Willebrand factor, von Willebrand factor preproprotein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
F8VWF, F8VWF, VWD, VWF, vWF, VWF |
| Gene name synonims: |
F8VWF, F8VWF, VWD, VWF, vWF, VWF |
| Other gene names: |
F8VWF, F8VWF, VWD, VWF, vWF, VWF |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
RFF-VIII R/2 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
As such the antibody is a potent inhibitor of vWF activity, It also inhibits platelet adhesion to glass beads, It can completely neutralise ristocetin-induced platelet aggregation, It stabilises circulating Factor VIII by binding to it and protecting it from cleavage and delivers it to sites of vascular injury, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Symptoms might include nosebleeds, The antibody does not recognise human Factor VIII, The epitope recognised is present only on the intact multimeric form of vWF and is abolished by mild denaturation with SDS, This particular antibody might cross react with speacies outside of the listed ones, Various forms of vWD exist with differing severities, _x000D__x000D_Clone RF-VIII R/2 has a high affinity for an epitope within the platelet GPIb-binding site that is responsible for biological activity, _x000D__x000D_Clone RF-VIII R/2 may be used to detect vWF in immunoassays in combination with clone RFF-VIII R/1 as a capture reagent, _x000D__x000D_Hereditary or acquired defects in vWF lead to von Willebrand disease (vWD), a blood glycoprotein involved in blood coagulation, also known as Factor VIII related antigen, bleeding gums, characterised by varying degrees of susceptibility to bleeding, determined by the type of defect, easy bruising, menorrrhagia or gastrointestinal bleeding, platelet binding to the subendothelium and ristocetin-induced binding of vWF to platelets, vWF also promotes the adhesion of platelets to sites of vascular damage by forming a molecular bridge between collagen on exposed endothelial cells and the GPIb binding sites of platelets circulating in the blood, vWF circulates in the blood as large multimers, with each monomer (250kDa) containing a number of specific domains, VON WILLEBRAND FACTOR This item recognises human von Willebrand factor (vWF) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Frozen (IHC), Protein Purification, RadioImmunoassay (RIA), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
VON WILLEBRAND FACTOR |
| Short name: |
MOUSE Anti-HUMAN VON WILLEBRAND FACTOR Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens VON WILLEBRAND FACTOR (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
12727 |
| Gene: |
VWFP1 |
More about : VWFP1 |
| Long gene name: |
von Willebrand factor pseudogene 1 |
| Synonyms gene: |
F8VWFP F8VWFL VWFP |
| Synonyms gene name: |
von Willebrand factor pseudogene |
| Locus: |
22q11, 1 |
| Discovery year: |
1989-04-24 |
| GenBank acession: |
X66120 |
| Entrez gene record: |
7451 |
| RefSeq identity: |
NG_001212 |
| Havana BLAST/BLAT: |
OTTHUMG00000143725 |