| Also known as: |
CD252 |
| Other names: |
OX40 ligand, OX40 ligand, Tumor necrosis factor ligand superfamily member 4, member 4, tumor necrosis factor (ligand) superfamily, tumor necrosis factor ligand superfamily member 4, tumor necrosis factor ligand superfamily member 4 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD252 |
| Other gene names: |
OX40L, Ox40l, Ox40l, Tnfsf4, Txgp1, Tnfsf4 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
ATM-2 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Rat (Rattus norvegicus) |
| Specificity and cross-reactivity: |
CD252/OX40 interaction has been implicated in HTLV-1 associated diseases including myelopathy and adult T cell leukaemia, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone ATM-2 has been shown to block the co-stimulatory activity of CD252 on rat T cell proliferation, _x000D__x000D_The interaction of CD252 with its receptor OX40/CD134, a 22kDa type II transmembrane glycoprotein and member of the TNF superfamily, acts as a co-stimulator of T cell activation, and also by vascular endothelium, and also with the autoimmune diseases rheumatoid arthritis and inflammatory bowel disease, and is also important in activated B cell proliferation and secretion of immunoglobulins (Igs), expressed by antigen-presenting cells including activated dendritic cells and B cells, otherwise known as OX40L or CD134L, proliferation and both Th1 and Th2 cytokine production, CD252 This item specifically recognises rat CD252 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD252 |
| Short name: |
MOUSE Anti-RAT CD252 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MOUSE antibody to-RAT CD252 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11934 |
| Gene: |
TNFSF4 |
More about : TNFSF4 |
| Long gene name: |
tumor necrosis factor superfamily member 4 |
| Synonyms gene: |
TXGP1 |
| Synonyms gene name: |
34kD tumor necrosis factor (ligand) superfamily, member 4 , tax-transcriptionally activated glycoprotein 1 |
| Synonyms: |
OX-40L gp34 CD252 |
| Locus: |
1q25, 1 |
| Discovery year: |
1993-12-15 |
| GenBank acession: |
D90224 |
| Entrez gene record: |
7292 |
| Pubmed identfication: |
1996093 8076595 |
| Classification: |
Tumor necrosis factor superfamily CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000034838 |