| Also known as: |
CD152 |
| Other names: |
CD152 antigen, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte protein 4, cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated protein 4, cytotoxic T-lymphocyte protein 4 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD152 |
| Other gene names: |
CTLA-4, Cd152, Cd152, Ctla-4, Ctla4, Ly-56, Ctla4 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
1B8 |
| Host organism: |
Hamster |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD152 binds the same ligands as CD28, CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion, CD152 is not detected on naï, However, It may also be used to enhance tumour immunity, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis, _x000D__x000D_In mice, _x000D__x000D__x000D_Clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells, a structural homolog for CD28, binding of CD152 inhibits it, but with much higher affinity, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, namely CD80 (B7, suggesting a critical role for CD152 in limiting T-cell responses, while binding of CD28 enhances T cell function, 1) and CD86 (B7, 2), CD152 This item recognises mouse CD152, ve T-cells and is induced upon T-cell activation |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD152 |
| Short name: |
HAMSTER ANTI MOUSE CD152 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAMSTER antibody to MOUSE CD152 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2505 |
| Gene: |
CTLA4 |
More about : CTLA4 |
| Long gene name: |
cytotoxic T-lymphocyte associated protein 4 |
| Synonyms gene: |
CELIAC3 IDDM12 |
| Synonyms gene name: |
celiac disease 3 insulin-dependent diabetes mellitus 12 |
| Synonyms: |
CD152 CD GSE |
| Locus: |
2q33, 2 |
| Discovery year: |
1989-05-25 |
| Entrez gene record: |
1493 |
| Pubmed identfication: |
3220103 8817351 |
| RefSeq identity: |
NM_005214 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000132877 |