| Also known as: |
MALT1 |
| Other names: |
MALT associated translocation, MALT lymphoma-associated translocation, MALT lymphoma-associated translocation, MALT-lymphoma associated translocation, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase, caspase-like protein, mucosa associated lymphoid tissue lymphoma translocation gene 1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, paracaspase, mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform a |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MALT1 |
| Other gene names: |
MALT1, MLT, MLT, MLT1, MALT1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
50 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
In T-cells, In normal lymphocytes, MALT1 is recruited by activated CARMA1, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Studies suggest that overexpression of MALT1, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_MALT1 was initially identified as a recurrent translocation t(11, _x000D__x000D_This item is reported to recognise both MALT1 and the MALT1-API2 fusion protein, a 93kD paracaspase which has been reported to demonstrate proteolytic activity, along with Bcl-10, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent, or expression of the API2-MALT1 fusion protein, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB, which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2, 18)(q21:q21) in mucosal-associated lymphomas, MALT1 This item recognises human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
MALT1 |
| Short name: |
MOUSE Anti-HUMAN MALT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens mucosa associated lymphoid tissue lymphoma translocation gene 1 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
IMD12 and MLT and MLT1, MALT1 and IDBG-3930 and ENSG00000172175 and 10892, MALT1 and IDBG-644866 and ENSBTAG00000027916 and 504994, Malt1 and IDBG-154592 and ENSMUSG00000032688 and 240354, nuclei, protein self-association, this GO :0001923 and B-1 B cell differentiation and biological process this GO :0002020 and protease binding and molecular function this GO :0002237 and response to molecule of bacterial origin and biological process this GO :0002726 and positive regulation of T cell cytokine production and biological process this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006508 and proteolysis and biological process this GO :0006952 and defense response and biological process this GO :0007250 and activation of NF-kappaB-inducing kinase activity and biological process this GO :0008233 and peptidase activity and molecular function this GO :0009620 and response to fungus and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019209 and kinase activator activity and molecular function this GO :0031398 and positive regulation of protein ubiquitination and biological process this GO :0032449 and CBM complex and cellular component this GO :0032743 and positive regulation of interleukin-2 production and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042098 and T cell proliferation and biological process this GO :0042113 and B cell activation and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043234 and protein complex and cellular component this GO :0043621 and protein self-association and molecular function this GO :0045087 and innate immune response and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050856 and regulation of T cell receptor signaling pathway and biological process this GO :0050870 and positive regulation of T cell activation and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051168 and nuclear export and biological process this GO :0051259 and protein oli this GO merization and biological process, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0004197 : cysteine-type endopeptidase activity and also this GO :0004842 : ubiquitin-protein transferase activity and also this GO :0004871 : signal transducer activity and also this GO :0005515 : protein binding and also this GO :0008233 : peptidase activity and also this GO :0019209 : kinase activator activity and also this GO :0043621 : protein self-association, this GO :0004197 : cysteine-type endopeptidase activity, this GO :0004842 : ubiquitin-protein transferase activity, this GO :0004871 : signal transducer activity, this GO :0005515 : protein binding, this GO :0008233 : peptidase activity, this GO :0019209 : kinase activator activity, this GO :0043621 : protein self-association, mucosa associated lymphoid tissue lymphoma translocation gene 1 |
| Identity: |
6819 |
| Gene: |
MALT1 |
More about : MALT1 |
| Long gene name: |
MALT1 paracaspase |
| Synonyms gene: |
MLT |
| Synonyms gene name: |
mucosa associated lymphoid tissue lymphoma translocation gene 1 |
| Synonyms: |
PCASP1 |
| Synonyms name: |
MALT1 protease paracaspase 1 |
| Locus: |
18q21, 32 |
| Discovery year: |
1999-08-02 |
| Entrez gene record: |
10892 |
| Pubmed identfication: |
10339464 10406266 10523859 11090634 26377317 |
| RefSeq identity: |
NM_006785 |
| Classification: |
Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000132761 |