| Also known as: |
P2X7 |
| Other names: |
7, ATP receptor, ATP receptor, P2X purinoceptor 7, P2X purinoceptor 7, P2X7 purinoceptor, P2X7 receptor, P2Z receptor, P2Z receptor, Purinergic receptor, ligand-gated ion channel, purinergic receptor P2X, P2X purinoceptor 7 isoform a |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
P2X7 |
| Other gene names: |
AI467586, P2X(7), P2X7, P2X7R, P2rx7, P2x7, P2rx7 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2b |
| Clone: |
Hano43 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
As such, It is a cation selective ion channel that opens up on binding of extracellular ATP, Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP, P2X7 blockers might be useful as anti-inflammatory agents, P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation, Should ATP stimulation continue the cell will become irreversibly damaged and die, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da, The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic, This particular antibody might cross react with speacies outside of the listed ones, also known as P2X7, P2X7 This item recognises the P2X purinoceptor 7 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunofluorescence (IF) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
P2X7 |
| Short name: |
RAT ANTI MOUSE P2X7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE P2X7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8537 |
| Gene: |
P2RX7 |
More about : P2RX7 |
| Long gene name: |
purinergic receptor P2X 7 |
| Synonyms gene name: |
7 , ligand-gated ion channel, purinergic receptor P2X |
| Synonyms: |
P2X7 MGC20089 |
| Locus: |
12q24, 31 |
| Discovery year: |
1997-10-09 |
| GenBank acession: |
Y09561 |
| Entrez gene record: |
5027 |
| Pubmed identfication: |
9038151 9826911 |
| RefSeq identity: |
NM_002562 |
| Classification: |
Purinergic receptors P2X |
| Havana BLAST/BLAT: |
OTTHUMG00000169153 |