| Also known as: |
CD178 |
| Other names: |
CD95 ligand, CD95 ligand, CD95-L, CD_antigen: CD178Cleaved into the following 4 chains:Tumor necrosis factor ligand superfamily member 6, Fas antigen ligand, Fas antigen ligand, Fas ligand, Fas ligand (TNF superfamily, FasL, Soluble Fas ligand, Tumor necrosis factor ligand superfamily member 6, Tumor necrosis factor ligand superfamily member 6, generalized lymphoproliferative disease, member 6), membrane form, sFasL, soluble formAlternative name(s):Receptor-binding FasL ectodomain, tumor necrosis factor ligand superfamily member 6, tumor necrosis factor ligand superfamily member 6 isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD178 |
| Other gene names: |
APL, APT1LG1, Apt1lg1, CD178, CD95-L, CD95-L, CD95L, Cd95l, Fas ligand, Fas-L, FasL, FasL ICD, Fasl, Faslg, Faslg, SPA, Tnfsf6, Tnfsf6, gld, gld, sFasL, Fasl |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
MFL4 |
| Host organism: |
Hamster |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The binding of CD178 to its receptor CD95 (Fas), The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses, _x000D__x000D_Clone MFL4 is reported to block CD178/CD95 induced apoptosis, a 40kDa type II transmembrane glycoprotein and member of the TNF/NGF superfamily, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis, chemotherapeutic agents and viral infection, expressed by activated T cells and NK cells, heat shock, induces Fas-mediated apoptosis of target cells, otherwise known as Fas Ligand/ CD95L, which can be induced on a variety of cells by radiation, CD178 This item recognises both mouse and rat CD178 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD178 |
| Short name: |
HAMSTER ANTI MOUSE CD178 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAMSTER antibody to MOUSE CD178 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11936 |
| Gene: |
FASLG |
More about : FASLG |
| Long gene name: |
Fas ligand |
| Synonyms gene: |
APT1LG1 TNFSF6 |
| Synonyms gene name: |
member 6 Fas ligand (TNF superfamily, member 6) , tumor necrosis factor (ligand) superfamily |
| Synonyms: |
FasL CD178 |
| Locus: |
1q24, 3 |
| Discovery year: |
1994-12-09 |
| GenBank acession: |
U11821 |
| Entrez gene record: |
356 |
| Pubmed identfication: |
7826947 9022072 |
| Classification: |
Endogenous ligands Tumor necrosis factor superfamily CD molecules Death inducing signaling complex |
| Havana BLAST/BLAT: |
OTTHUMG00000034841 |
| Locus Specific Databases: |
FASLGbase: Mutation registry for Autoimmune lymphoproliferative syndrome, type 1B (ALPS1B) (previously known as TNFSF6base) LRG_58 |