| Also known as: |
SOS1 |
| Other names: |
1, N/A, SOS-1, Son of sevenless homolog 1, gingival fibromatosis, guanine nucleotide exchange factor, hereditary, son of sevenless homolog 1, son of sevenless homolog 1 (Drosophila), son of sevenless homolog 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
SOS1 |
| Other gene names: |
GF1, GGF1, GINGF, HGF, NS4, SOS-1, SOS1, SOS1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
SOS-1 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), a ubiquitously expressed 150kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), bleeding diathesis and distinctive facial features, by acting as a regulator of Ras and Rac/Rho GTPases, characterized by short stature, congenital heart malformation, which plays a role in growth and differentiation signalling pathways and in actin reorganization, SOS1 This item specifically recognises SOS1 (son of sevenless homolog 1) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
SOS1 |
| Short name: |
MOUSE Anti-SOS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MOUSE antibody to-SON Desoxyribonucleic acid binding protein on sevenless homolog 1 (Drosophila) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
GF1 and GGF1 and GINGF and HGF and NS4, Plasma membranes, SOS1 and IDBG-47279 and ENSG00000115904 and 6654, SOS1 and IDBG-632726 and ENSBTAG00000011643 and 537682, Sos1 and IDBG-199949 and ENSMUSG00000024241 and 20662, protein heterodimerization activity, this GO :0003677 and DNA binding and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005088 and Ras guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005100 and Rho GTPase activator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0030168 and platelet activation and biological process this GO :0032318 and regulation of Ras GTPase activity and biological process this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045742 and positive regulation of epidermal growth factor receptor signaling pathway and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050900 and leukocyte migration and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0051057 and positive regulation of small GTPase mediated signal transduction and biological process this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005088 : Ras guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005100 : Rho GTPase activator activity and also this GO :0005515 : protein binding and also this GO :0017124 : SH3 domain binding and also this GO :0046982 : protein heterodimerization activity, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005088 : Ras guanyl-nucleotide exchange factor activity, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005100 : Rho GTPase activator activity, this GO :0005515 : protein binding, this GO :0017124 : SH3 domain binding, this GO :0046982 : protein heterodimerization activity, son of sevenless homolog 1 (Drosophila) |
| Identity: |
11187 |
| Gene: |
SOS1 |
More about : SOS1 |
| Long gene name: |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
| Synonyms gene: |
GINGF |
| Synonyms gene name: |
1 son of sevenless homolog 1 (Drosophila) , gingival fibromatosis, hereditary |
| Synonyms: |
HGF GF1 |
| Locus: |
2p22, 1 |
| Discovery year: |
1993-10-27 |
| GenBank acession: |
L13857 |
| Entrez gene record: |
6654 |
| Pubmed identfication: |
8276400 10995566 |
| RefSeq identity: |
NM_005633 |
| Classification: |
Rho guanine nucleotide exchange factors Pleckstrin homology domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000102109 |
| Locus Specific Databases: |
LRG_754 |