| Also known as: |
RICIN |
| Other names: |
N/A, Ricin, Ricin precursor, rRNA N-glycosidase, Ricin |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
RICIN |
| Other gene names: |
N/A, N/A, N/A, RCOM_2159910 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
RB999 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Plants |
| Specificity and cross-reactivity: |
A and B, It has no cross-reactivity with agglutinin RCA<, It is toxic when inhaled, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA, The A chain can inactivate a few thousand ribosomes per minute, The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A chain into the cell, The area from which the adenine is removed is essential for binding of elongation factors, The ease of extraction and distribution makes it a potential candidate for biological warfare although it is less stable than other agents, The ricin toxin consists of two chains, This particular antibody might cross react with speacies outside of the listed ones, Treatment is symptomatic and supportive, Without the B chain, _x000D__x000D_Ricin is easily extracted from the castor bean (<, a 60kDa glycoprotein, although a vaccine has been developed, and the lethal dose for humans is very small, covalently linked by a disulfide bond, destroying it leaves the ribosome inactive and unable to support protein synthesis, ingested or injected and there is no known antidote, meaning that a single ricin A chain can kill a cell, much faster than the cell can replace them, such as anthrax, the A chain has very low toxicity, with long term organ damage likely in survivors, ), ), /i>, /sub>, /sub>, 120<, 60<, RICIN This item recognises the B chain of the ricin toxin (RCA<, Ricinus communis<, _x000D__x000D__x000D_, i>, sub>, sub> |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
RICIN B CHAIN |
| Short name: |
MOUSE Anti-RICIN B CHAIN Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MOUSE antibody to-RICIN B epitope (Antibody to) |
| Alternative technique: |
antibodies |