| Also known as: |
CD263 |
| Other names: |
Antagonist decoy receptor for TRAIL/Apo-2L, DcR1, Decoy TRAIL receptor without death domain, Decoy receptor 1, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL receptor without an intracellular domain, TRAIL-R3, Tumor necrosis factor receptor superfamily member 10C, antagonist decoy receptor for TRAIL/Apo-2L, cytotoxic TRAIL receptor-3, decoy TRAIL receptor without death domain, decoy receptor 1, decoy without an intracellular domain, lymphocyte inhibitor of TRAIL, member 10c, tumor necrosis factor receptor superfamily, tumor necrosis factor receptor superfamily member 10C, tumor necrosis factor receptor superfamily member 10C |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD263 |
| Other gene names: |
CD263, DCR1, DCR1, DCR1-TNFR, DcR1, LIT, LIT, TNFRSF10C, TRAIL receptor 3, TRAIL-R3, TRAIL-R3, TRAILR3, TRAILR3, TRID, TRID, TNFRSF10C |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
2B8 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
As the receptor does not possess cytoplasmic death domains it cannot induce apoptosis, CD263 is a member of the tumour necrosis factor (TNF) receptor superfamily that binds to TNF-related apoptosis inducing ligand (TRAIL), CD263 is expressed in normal tissues including heart, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_The 2B8 antibody does not inhibit DcR1 (CD263) inhibitory function in TRAIL-induced apoptosis, a 60 Kd cell surface protein, but instead plays an important role in inhibiting TRAIL-induced apoptosis, but weakly expressed in tumour cells, skeletal tissues and peripheral blood neutrophils, which is otherwise known as decoy receptor 1 (DcR1), CD263 Recognises human CD263 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunoprecipitation (IP) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD263 |
| Short name: |
MOUSE Anti-HUMAN CD263 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD263 (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
11906 |
| Gene: |
TNFRSF10C |
More about : TNFRSF10C |
| Long gene name: |
TNF receptor superfamily member 10c |
| Synonyms gene name: |
decoy without an intracellular domain , member 10c, tumor necrosis factor receptor superfamily |
| Synonyms: |
DcR1 TRAILR3 LIT TRID CD263 |
| Locus: |
8p21, 3 |
| Discovery year: |
1998-12-04 |
| GenBank acession: |
AF012536 |
| Entrez gene record: |
8794 |
| Pubmed identfication: |
9314565 9325248 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000097844 |