| Also known as: |
CD172a |
| Other names: |
Bit, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, inhibitory receptor SHPS-1, macrophage fusion receptor, myd-1 antigen, p84, signal-regulatory protein alpha, tyrosine phosphatase SHP substrate 1, tyrosine-protein phosphatase non-receptor type substrate 1, tyrosine-protein phosphatase non-receptor type substrate 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD172a |
| Other gene names: |
BIT, BIT, Bit, CD172A, MFR, MFR, MYD-1, MYD1, P84, PTPNS1, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, SHPS1, SIRP, SIRP, SIRPA, Sirp-alpha-1, Sirp-alpha-2, SIRPA |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
15-414 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Ligand binding of CD172a to integrin-associated protein CD47, Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, PDGFR, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, These then act as regulators of cellular function, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD172a acts as a substrate for several activated tyrosine kinases, a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, also known as signal-regulatory protein alpha, dendritic cells (DCs), including EGFR, including granulocytes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs, macrophages, mast cells and haematopoietic stem cells, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways, through dephosphorylation of specific substrates, CD172a Is specific for human CD172a |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Frozen (IHC), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD172a |
| Short name: |
MOUSE Anti-HUMAN CD172a Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens CD172a (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
9662 |
| Gene: |
SIRPA |
More about : SIRPA |
| Long gene name: |
signal regulatory protein alpha |
| Synonyms gene: |
PTPNS1 |
| Synonyms gene name: |
non-receptor type substrate 1 signal-regulatory protein alpha , protein tyrosine phosphatase |
| Synonyms: |
SHPS1 SIRP MYD-1 BIT P84 SHPS-1 SIRPalpha CD172a SIRPalpha2 MFR SIRP-ALPHA-1 |
| Locus: |
20p13 |
| Discovery year: |
1999-03-19 |
| GenBank acession: |
D86043 |
| Entrez gene record: |
140885 |
| Pubmed identfication: |
9070220 9062191 16339511 |
| RefSeq identity: |
NM_080792 |
| Classification: |
C1-set domain containing CD molecules Signal regulatory proteins V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031682 |