| Also known as: |
CD223 |
| Other names: |
Lymphocyte activation gene 3 protein, N/A, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3, lymphocyte activation gene 3 protein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD223 |
| Other gene names: |
CD223, LAG-3, LAG-3, Lag3, Ly66, Lag3 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
C9B7W |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion, Clone C9B7W recognises an epitope within the D2 domain of CD223, Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The antibody is reported to block the <, This particular antibody might cross react with speacies outside of the listed ones, a 70kD activation-induced cell surface molecule that is also referred to as CD223, function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II , /I>, CD223 This item recognises murine lymphocyte activation gene-3 (LAG-3), I>, in vitro< |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD223 |
| Short name: |
RAT ANTI MOUSE CD223 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD223 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6476 |
| Gene: |
LAG3 |
More about : LAG3 |
| Long gene name: |
lymphocyte activating 3 |
| Synonyms gene name: |
lymphocyte-activation gene 3 |
| Synonyms: |
CD223 |
| Locus: |
12p13, 31 |
| Discovery year: |
1991-06-03 |
| Entrez gene record: |
3902 |
| RefSeq identity: |
NM_002286 |
| Classification: |
CD molecules Immunoglobulin like domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000169197 |